[quote]Mattlebee wrote:
pushharder wrote:
Since I know we have at least one MD who participates in this thread I thought he and maybe some others might find this article interesting:
Mutations: The Raw Material for Evolution?
by Barney Maddox, M.D.
“Positive” Mutations
Biology textbooks in theory present positive and negative mutations to students as though these were commonplace and roughly equal in number. However, these books fail to inform students that unequivocally positive mutations are unknown to genetics, since they have never been observed (or are so rare as to be irrelevant).
There are prostitutes in some of the most AIDS-ridden parts of Africa that despite being regularly exposed to HIV don’t get infected. This is due to a mutation in a protein on their white blood cells that means the virus can’t get in. In this situation it can be described as a positive mutation. [/quote]
This was actually the first thing that came to my mind. I can’t be positive, but I believe it’s something along the lines of 4% of the population in certain areas have this mutation and are immune to HIV. Talk about a great mutation.
O’ course, they’re still carriers because it’s in their blood…
[quote]
However, the biology textbooks, when discussing mutation in evolution, only discuss the very rare “positive” mutation, like sickle cell anemia.
It’s the premier example of a point mutation disease and as a disease it can hardly be positive (unless you happen to also have the worse disease malaria).[/quote]
It is a disease, but it DOES confer a survival advantage in many parts of rural Africa, and thus could be considered positive IMHO.
One thing to note is that a mutation doesn’t really have to be positive, it just has to confer enough of an advantage that the genes are passed on. If you make it to mating time-- and others don’t (because they have, say, MALARIA)–then it’s done it’s job, and it can now kill you (by sickling and blocking off organs) without any ill effects on the species. So, positive from a survival standpoint doesn’t actually have to mean positive, or longer life. Just good enough to mate and pass on genes.