[quote]Cortes wrote:
Sifu did you even read the article you linked? I did. Here are a couple of excerpts. Emphasis mine:
[quote]
Still, the researchers note, the actual frequency of specific birth defects were relatively small, all ranging below one percent. That compares to an overall rate of all birth defects of about 2 percent in the general population.
Since last summer, U.S. guidelines have recommended against using Depakote in pregnancy, but Meador said it was still widely used across the country.
Although a few women with epilepsy may only respond to Depakote, often there are alternatives. “If a drug doesn’t work on a woman, you can try another,” said Meador.[/quote]
Better cut that useless piece of meat out of her. Its existence will certainly be meaningless. [/quote]
I read that. As I wrote depakote is one of the drugs they use it is not the only drug that is used. I get the distinct impression you are not grasping a very important concept regarding the medications used to prevent epileptic seizures. They do use just one drug and call it a day.
They use what is sometimes referred to as a “stack” of drugs. A stack of drugs is a combination of multiple drugs that are used simultaneously, at the same time. The benefit of a stack is it increases the chances of the desired results being achieved. The downside is toxicity issues are multiplied and if two or more drugs have the same toxicity issue the odds of there being a problem are increased.
So just because the chances of depakote causing a specific birth defects is below one percent when used alone that doesn’t mean the odds of a defect remain the same if it is stacked with another toxic drug or combination of toxic drugs. What I do know is that these kinds of odds aren’t additive they multiply.
So if the incidence of Spina Bifida is increased twelves times by depakote if any of the other drugs in the stack increase the likelihood it is going to be a multiple of twelve. I don’t know if there are any figures for what the chances are when it is stacked with other but I do know that no reputable researcher would knowingly engage in such a test
"The odds of spina bifida, for instance, were more than 12 times higher in these babies compared to those whose mothers didn’t take epilepsy drugs. Abnormal skull development, cleft palate, holes in the heart’s walls, extra fingers or toes, smaller limbs, and urinary problems were also more frequent in the Depakote group, with odds increased up to seven times.
And five of these defects appeared to be specific to Depakote compared with other epilepsy drugs."
Also getting one birth defect doesn’t decrease the chances of getting any of the others.
These are severe birth defects whose likelihood any rational person would want to do everything possible to minimize by consulting with their doctor and either adjusting their intake or eliminating altogether certain drugs from the combination of multiple drugs they are taking. The woman in this case did none of that because she is not capable of making a rational decision regarding a child’s welfare.