NRF2 = Nuclear factor erythroid 2-related factor 2.
nfstern
January 19, 2024, 4:39pm
22
TC_Luoma:
Alternately, aminoguanidine, once an investigational drug for the treatment of diabetic neuropathy, also reduces glycation directly, even having been found to prevent AGE cross-linking in the walls of arteries. The substance, while somewhat hard to find, is available as an over-the-counter supplement.
SuperSmart has an Aminoguanidine supplement. Each capsule is 75mg. The bottle says take 300mg spread over the day at mealtimes. Do you have a recommended protocol regarding dosage and when to take it?
nfstern
January 19, 2024, 4:52pm
23
Digging a little deeper into the rabbit hole, it appears that Agmatine is an endogenous aminoguanidine compound.
Agmatine is an endogenous neuromodulator that, based on animal studies, has the potential for new drug development. As an endogenous aminoguanidine compound (1-amino-4-guanidinobutane), it is structurally unique compared with other monoamines....
Can you cast some light here on how to make sense of this?