Umm no because the whole “clean my receptors” thing is a bunch of crap. If anything receptor population will upgrade in the presence of continued high androgen levels.
By “cleaning receptors” to maximize gains I think you are referring to reversing the receptor downgrade during a cycle.
In the presence of high testosterone and/or low estrogen the density and/or sensitivity of androgen receptors (AR) will diminish. By cycling (taking time off between cycles) your body returns to its normal level or testosterone production. Since this is lower than it is on cycle your body responds by increasing the density and/or sensitiviey of ARs to maintain homeostasis.
This is why even long-term advanced users cycle. Prisoner 22 has a thread about the efficacy of cycling to replenish AR integrity, but my post here just about sums it up without the sciency mumbo-jumbo.
To answer your question, taking time off will assure a “cleaning” of ARs and will maximize the next cycle’s gains.
There is also the issue of how E competes with T at the T receptors and the concept of E docking in the T receptors and blocking [interference] their function. Elevated E decreases the effect of T on the T receptors and otherwise lowers FT by increasing SHBG and down regulates T production via negative feedback on the HPTA. … and lowers libido and has other negative mental and energy effects. If you want T to work better, E is more of an issue than cleaning receptors.
When a receptor is activated by a hormone, the receptor is drawn into the cell and then the appropriate actions follow. New receptors are expressed on the cell’s surface. Receptors are routinely renewed. If one has too much of the wrong fats and not enough EFAs (essential fatty acids [such as fish oils and olive oil] then the cell walls will not work optimally.
The concept of cell wall function/permeability also is part of syndrome-x aka metabolic syndrome and insulin resistance. Your heath and vitality cannot exceed the health of individual cells. A lot is known about things and the cellular level. This forms the logic behind many supplements and diets.
If you want your receptors to work better, take care of the needs of your cells, other benefits will follow. Avoid corn oil and meat/dairy fats when you can. Do not use hydrogenated vege oils. Take fish oils and use olive oil when you can.
The benefits will have the time scale of cellular renewal. That is faster when young and slow when old. The EFA content of the brain, retina and nerves is fixed as these cells mostly do not renew in a lifetime. That is why EFAs in the diet of mothers is critical.