OK, the first time I saw this I thought it might have been a mistake. But I have heard it too many times now to ignore it.
So please, can someone enlighten me on how this drug works as an ergogen. And if one were to take this drug for the purpose of building lean mass, how much should one take.
My last and most important concern is that If one were to be on a drug like this on a regular basis for an extended peroid of time. would this person develope a depedency on these types of drugs in order to obtain an erection in the same way as they did before being on the drug? Is it even a good idea to take cialis other than to counter ED?
I have not heard any ergo claims or seen any research supporting it, but I also haven’t been looking. Based on the MOA (listed below) of the med,if there is some sort of ergogenic property, my guess is that it would be through some type of NO mediated influence. Let the NO debates begin.
Mechanism of Action: Tadalafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). The physiologic mechanism of erection of the penis involves release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation. Nitric oxide then activates the enzyme guanylate cyclase, which results in increased levels of cGMP. Cyclic guanosine monophosphate causes smooth muscle relaxation in the corpus cavernosum thereby allowing inflow of blood; the exact mechanism by which cGMP stimulates relaxation of smooth muscles has not been determined. Phosphodiesterase type 5 is responsible for degradation of cGMP in the corpus cavernosum. Tadalafil enhances the effect of NO by inhibiting PDE5 thereby raising concentrations of cGMP in the corpus cavernosum. Tadalafil has no direct relaxant effect on isolated human corpus cavernosum and, at recommended doses, has no effect in the absence of sexual stimulation. In vitro studies show that tadalafil is selective for PDE5 and is >10,000-fold more potent for PDE5 than for PDE1, PDE2, PDE4, and PDE7, which are found in the heart, brain, blood vessels, liver, leukocytes, skeletal muscle, and other organs. Tadalafil is >10,000 fold more potent for PDE5 than for PDE3 found in the heart and blood vessels. Also, tadalafil has 700-fold greater selectivity for PDE5 versus PDE6, an enzyme found in the retina and involved in phototransduction. Compare this selectivity to the selectivity of sildenafil which has only a 10-fold selectivity for PDE5 versus PDE6. This lower selectivity of sildenafil for PDE5 vs PDE6 is thought to be the basis for abnormalities related to color vision observed with higher doses or plasma concentrations of sildenafil. Further, tadalafil is >9000-fold more potent for PDE5 than for PDE8, PDE9, and PDE10 and 14-fold more potent for PDE5 than for PDE11A1, an enzyme found in human skeletal muscle. Inhibition of human recombinant PDE11A1 activity occurs at tadalafil concentrations within the therapeutic range. The physiological role and clinical effects of PDE11 inhibition in humans have not been elucidated.
Phosphodiesterase type 5 (PDE5) is also abundant in lung tissue and esophageal smooth muscle. Inhibition of PDE5 in lung tissue results in pulmonary vasodilation which can be effective in treating pulmonary hypertension. Inhibition of esophageal smooth muscle PDE5 can cause a marked reduction in esophageal motility as well as in lower esophageal sphincter (LES) tone. These effects may be beneficial in certain motor disorders involving the esophagus such as diffuse spasm, nutcracker esophagus, and hypertensive LES. However, the reduction in LES tone can worsen the symptoms of gastroesophageal reflux disease (GERD). Dyspepsia is one of the most common adverse reactions associated with PDE inhibitor therapy.
Don’t know for sure but this sounds like a shit idea. For starters, cialis has a common side affect of causing lower back pain. I experianced this (no I don’t have ed, I just like to smash pussy). It doesn’t help squatting or dl workouts at all. Also after taking it for awhile you’re probably not going to be too thrilled with what your regular wood feels like.
Take it when the time is right ie. a new peice that you wanna put on lockdown. Or some “quality time” away from your busy schedule with your lady, or at the end of cycle when you Johson Rod isn’t working like it did on 1 gram of test.
Thank you for your detailed information dr. Ryan. So it seams taking an NO2 type supplement would be more practical. (or just eating a bunch of banannas throughout the day0>
Wideguy… yea, Ill take your advice. The reason I got cialis in the first place was because of during and post cycle. I am one of those guys whose sex drive goes down when on a heavy cycle.
Hey Dr. Ryan, are you trying to make me look bad? Kidding, nice post.