Long story short, I’ve had discomfort in my right side for the past year and a half. After seeing 2 GIs and having many tests done, (including a liver biopsy) the docs had no answers for me. All tests were unfounded.
I’ve been tested for Celiac’s twice. Both negative.
Is it possible that a wheat/gluten sensitivity be a possibility despite what the blood work says?
I’m trying to figure out what’s wrong with me.
Thanks.
some say yes, some say no. There’s a lot of conflicting opinion in the medical community on just how many people are sensitive to gluten.
The only way to be sure is to cut out any gluten for 6 weeks, and I mean ZERO gluten during that time, then reevaluate.
You might not feel different, or you might feel much better. It’s definitely worth a try
Look up the difference between auto-immune reactions, sensitivity, and allergies to gluten. Only the auto-immune reaction will show on a immunoglobin blood test I believe which is why you may not ping for celiac.
How were you tested? Blood testing or endoscopy? I’ve had 1 tell me I had it and the other tell me I don’t. After all the reading I’ve done about gliadin in general, I try to avoid it as much as possible due to any amount of inflammation it may cause. I’ll still occasionally enjoy a beer or a greasy burger or pizza or something but luckily gluten free options are becoming more available so I can find different sources and not jack up my stomach.
As rds said, the only real way to know is to avoid it and see how you feel. I definitely feel less bloated when I dont have gluten. When in doubt, it’s just better to remove it.
I have Celiac’s myself (positive immunoglobulin blood test) so I have been asked many similar questions and I consider myself well read on the topic. Many people generate an innate immune response to gliadin peptides and other molecules in wheat, which will not show a positive result for antibody tests or for that matter by endoscopy.
A tissue biopsy is the only way to really gauge this sort of reaction, but this is highly invasive and totally unnecessary. I agree completely with the above suggestion to stick to a devote 6 week gluten free diet as this is the only way to really know if you are having a reaction to a wheat protein. Don’t try judging your results before 4 weeks of devout dieting because the peptides tend to hang around in your system so casual avoidance wont do a thing to help.
Odds are a little pain in the upper right gut region isn’t full blown Celiac, if you did have the MHC allotype specific to generating an adaptive immune response (antibody production and extensive autoimmunity, basically what shows up in the tests) your symptoms would most likely include diarrhea, reddening in the cheeks, muscle cramps and as in my case weight loss (not the good kind).
Many athletes, not necessarily body builders or powerlifters to my knowledge, have switched to gluten free diets because the innate response, which does have mild genetic predispositions based on brush border enzyme insufficiency and CXCR3 binding, does decrease athletic performance. This is because the mild inflammation generated in your gut hinders mineral and B12 uptake and of course the associated bloating and discomfort doesn’t help anyone.
Sorry for the wall of words, hope this sheds some light on the topic.
In addition you may try checking out rds’s gut health log thread in this forum. May be some useful stuff to get you running right. I used to get a lot more pain that felt like it was isolated to my intestines. As odd as it sounds, I found that when it was like that I would give myself a abdomen massage to hopefully get something moving (like if it was a blockage of some sort).
You could also investigate into liver cleanses and such. Bitters, which I’ve mentioned in that other thread, or John Meadows’ lemon drink are great for liver flushes. Some of the more intense liver cleanses supposedly get out whole host of gallbladder stones.
[quote]coolnatedawg wrote:
Look up the difference between auto-immune reactions, sensitivity, and allergies to gluten. Only the auto-immune reaction will show on a immunoglobin blood test I believe which is why you may not ping for celiac.
How were you tested? Blood testing or endoscopy? I’ve had 1 tell me I had it and the other tell me I don’t. After all the reading I’ve done about gliadin in general, I try to avoid it as much as possible due to any amount of inflammation it may cause. I’ll still occasionally enjoy a beer or a greasy burger or pizza or something but luckily gluten free options are becoming more available so I can find different sources and not jack up my stomach.
As rds said, the only real way to know is to avoid it and see how you feel. I definitely feel less bloated when I dont have gluten. When in doubt, it’s just better to remove it.[/quote]
I had a celiac panel done.
any other ideas as to what could be wrong?
i’ve had:
abdominal ultrasound
abdominal ct scan
liver biopsy
hemochromatosis test
celiac test
hepatitis test
all came back negative
[quote]ANIMAL M0THER wrote:
Long story short, I’ve had discomfort in my right side for the past year and a half. After seeing 2 GIs and having many tests done, (including a liver biopsy) the docs had no answers for me. All tests were unfounded.
I’ve been tested for Celiac’s twice. Both negative.
Is it possible that a wheat/gluten sensitivity be a possibility despite what the blood work says?
I’m trying to figure out what’s wrong with me.
Thanks.[/quote]
The proper term is non-celiac gluten sensitivity.
Celiac disease is determined by only one blood biomarker and intestinal villi atrophy. This is an extremely limited view. There are potentially over 40 problematic proteins within gluten containing foods and a number of other possible cross-sensitivities.
I’d highly suggest you get the Gluten panels done from Cyrex Labs. Also look into getting a food allergy test done (LEAP-MRT)
It’s only been 6 days, but it seems the gluten-free diet is working. Discomfort has dramatically subsided to the point that it’s gone. Almost too good to be true.
When you guys mention positive immunoglobin bllod test-what is the connection between immunoglobin and gluten?
I ask because I have been having symptoms for a couple of years now which match with gluten sensitivity but I have had various stool,blood and other tests done and nothing has shown up(I was full sure my symptoms would be confirmed as gluten or yeast related) until lately on my most recent stool test.
I scored extremely low counts of Immunoglobin A,40 ug/ml when a healthy score would have been between 500-2000 ug/ml.
I too have been slowly losing muscle(while absolutely not anywhere near caloric deficit).Most noticeably around neck,shoulder blades,upper back.
Any advice greatly appreciated