Thanks man… I did what I could given the circumstances. You probably have more going on with @equel and @systemlord than you realize… poor you LOL
I actually think many can’t do higher amounts danny.
I think there are many doctors who start patients on low amounts, under 100mg/week.
Regardless of the outcome, you tried to help me and i thank you for that! You’re one of the good ones.
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You should have a chat with Dr. Neal Rouzier. Average total T of his patients is 1800 lol
I’m one of the ones who can’t handle higher amounts either, frankly. If my free T starts getting past 40-45, I don’t feel nearly as good. Anything below and issues return.
Holy Henshit, 1800!!! I’d be a sheet of acne and a dead wiener.
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You are killing me again man. 1800 ng/dL is the mean of his patients’ TT trough levels, peak levels, mid levels?
The Hct video is starting to make perfect sense now. What is the mean duration of TRT treatment of these patients under his care? Perhaps we can settle all these outstanding questions (at least I think about regarding compression of morbidity and short, medium and long-term optimization) doing an in depth study of his patient histories.
I’d love to see a plot of the distribution of Hct and cRP values over time superimposed on the mean T values. Perhaps there are just a few unlucky dudes like me who can’t handle the manly Hct in the mid 50s 
@yeti308 I bow to your superior estradiol and Hct handling manhood.
As I discussed with @highpull, I am perfectly willing to accept the potential improvement you get in some patient’s plasma viscosities with TRT which may offset Hct effect on whole blood viscosity with the “supra protocol”:
Life is short, I give you all a virtual fist bump.
He’s got most of his guys on the cream… so no trough.
I can get my levels WAY up, with virtually no impact on hct etc… but I don’t feel good there. I’ve determined my dose where I feel best at and that dose was never impacted by other factors (everything else in an ideal spot).
Many physicians I know don’t panic about HCT until it surpasses 60… no BS
I’ve never spoken with Neal directly but I know several people that do. They often tell me the same. I think Neal even mentioned it in one of his lectures that is on YouTube. If my memory serves me, I ‘think’ it is this one, but I could be mistaken:
Yep, I heard it, twice daily scrotal cream applications. Stated guys will often run at 2000.
He did not say, I came away with the impression that many of these guys were patients for 10-20 years.
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Always a trough but are you indicating it is being minimized by applying many times per day?
https://onlinelibrary.wiley.com/doi/full/10.1111/andr.12357
Tmax (3-5hr) from this study indicates absorption half life about 1 hour and elimination half life closer to 12 hours:
Gives me a chance to try out my new absorption + elimination model fitting the PK profile in the paper. Below is 100 mg per day of test split either twice or thrice daily:
To really minimize peak to trough variation, you’d need about 6x per day:
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Thanks very much for the info @highpull!
Given twice daily application would put you with rough PK profile in the blue so about a 29% peak to trough variation (1800/1400 = 1.29 at steady state).
Must be nice in this alternative world…I’d love to live there :-). Good for those guys (see I am trying to be more optimistic if they are indeed making it 20 years!).
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I’m taking once weekly injection.
Sorry, was addressing @dbossa but maybe he isn’t running that schedule or method either. I should say it must be nice to be able to do that type of dosage/TT levels. Now that I think of it, I think he said he is 2x weekly ester. Have a nice evening.
Correct
To be clear, I’ve never done the cream. Rouzier is big on it. Every other day shots is the best frequency I’ve found for me (I’ve tried it all). I feel so good where I am I really don’t want to switch to anything else.
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Why does this show 3x a day having greater swings than 2x a day? Typo?
Hey good eye!! Yeah going too fast, sorry about that. I corrected one of the plots above but missed the other. I’ll revise the typos. Thank you.
EDIT: all plots have been corrected. Thanks for taking a look @ncsugrad2002
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Do you do this Subq? Cyp?
Intramuscular… I’ve changed my tune about SubQ shots after learning more on the subject and I no longer promote using it. I use enanthate and feel the exact same if I use cypionate… no difference for me.
I can’t understand why some dudes get into topicals. Sounds like a mess. And honestly, I wanna keep getting my balls licked without worrying about my wife growing a mustache.
I’m intreagued- any pointers on what to read or a brief summary of why?
Guys doing SubQ and complaining… move them to IM and their levels went way up. I have never seen the opposite occur.
Gil did a deep dive on the subject:
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