So you only want to block the benefits a little bit? Why would anyone want to block the benefits???
Because just like testosterone E2 has a response relationship. There is an optimal range, whether you want to believe it or not.
Hormones can do different things and act different ways depending on their levels and the specific tissue.
I know but unfortunately there are many obese men using AIās because they canāt control E2 while theyāre taking TRT because they have absurdly low T due to the fact theyāre so obese. Visceral adipose tissue is a widely recognised endocrine organ nowadays that greatly contributes to the development of secondary hypogonadism, insulin resistance (via leptin resistance, other mechanisms) etc.
1500 was considered normal a few DECADES ago lol, now ref ranges are cutting off at like 650ng/dl here and bottoming out at sub 100ng/dl. Iāve seen in literature old ref ranges with a cutoff point of 1600ng/dl. Furthermore it does somewhat depend on free T, my CFT reaches near the top of the range at 800ng/dl. Environmental toxins, unhealthy lifestyle and various medications are creating a generation of low T, sub-fertile men (exaggerating obviously)
I have no qualms about running cycles, Iām running one now (340mg/wk, and Iām well aware of the cardiovascular, neurological and potentially nephrotoxicity implicated within my irresponsible decisions).
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Not according to the men researching it. There isnāt. Thatās where youāre stuck in the past. The men researching it have this down as proven fact at this point. Research will be coming out over the next few months. Just be patient.
My labs from 4 years ago show 1500 as the max.
Also, the obese men donāt have a high E2 issue. They have a testosterone deficiency issue. Give them testosterone and now they suddenly donāt have E2 issues even though their E2 levels remain the same or perhaps have even increased.
@increasemyt if you wish to block the effects of oestrogen on certain tissues, why not opt for a SERM like tamoxifen (well tamoxifen is a pro-drug, itās metabolites are the moreā¦ sermy drugs but ehh), aside from the potential neurotoxicity/ocular effects of SERMās, they donāt have the particular negative effects on oneās lipid profile
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But visceral adipose tissue contains aromatase, theoretically if theyāre taking sub Q test or IM test/whatever wouldnāt they theoretically aromatise at a higher rate compared with a normal individual or are they not correlated.
@unreal24278 absolutely. A SERM would be ideal to block at the breast receptors. Absolutely.
Here is a clip of podcast I did on the subject. Tell me what you think.
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Iāll certainly check it out when I get back from school, however my opinion doesnāt mean much, Iām merely an 18 year old young whippersnapper plagued with numerous health ailments trying to find his place in this harsh, unforgiving world.
If you optimize their free T, their higher levels of E2 suddenly are no longer concern. Iāve seen hundreds of cases like this.
Their E2 is high because they are obese. E2 isnāt hat caused their issues. Watch the clip and I explain in detail.
I personally do not use SERMās honestly I think they are highly toxic. But short periods of time, no biggie.
I do not see any particular negative effects on lipid profiles with proper usage of an AI, I have labs if you want to see them, have posted them for @dbossa And not jsut labs on me, numerous people.
Estrogen regulates lipid and glucose metabolism, like testosterone. So if you bury your E2, yea you will wreck your lipids.
If youāre 18 years old I now have mad respect for you because I donāt know anyone with your level of intellect at 18. Watch it and let me know what you think. If you like it you can watch the whole podcast here:
Iāve done several of these.
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No buddy. Your analysis is amazing. You just managed to bring peace to this thread.
Your knowledge, understanding and retention of information is great.
Age has nothing to do with ones ability in this case.
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Any reduction in E2 will cause a reduction in the benefits when it comes to lipids. We donāt touch E2 at all. Not whatsoever. Follow that free T. Thatās all you need to do.
Not true. I got 60 HDL labs to show with anastrozole. And yea I know itās about free T, remember thats how I knew you were a āhyper-secreterā.
Actually some labs before + after implementation of an AI would be interesting to see. The effects on oneās lipid profiles from various variables differ tremendously from person to person based on genetic predisposition (Iāve seen labs from someone on 50mg oxandrolone/day with a totally normal HDL, LDL, HDL/LDL ratio, sub-fractions, trigs, renal and hepatic function and otherās whose bloods are totally WRECKED!
Regardless if youāre comfortable posting those labs Iād be very interested
Feel free to create a bogus FB account and you can check out our group. Tons of docs there. Research provided daily. Right up your alley.
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K, will do!
Its just cause they took too much. If you look at labs on women taking AI for cancer treatment, their lipids are wrecked too.
It is about the suppression of estrogen. Kind of like how suppressing DHT gives men hypogonadism. But as mentioned in this forum the other, it takes 2 years to do that.
Just so weāre clear, Iām not whatsoever trying to get people to leave t-nation and join the FB group instead. You can do both. There is no competition going on here. There is just a TON of information there that we simply donāt see here. It is what it is. Different platform, different end game.