The testosterone dose response relationship, something @dbossa has yet to figure out.
Men with erectile dysfunction (ED) and/or diminished libido and documented testosterone deficiency are candidates for testosterone therapy. Adequate testosterone treatment can restore venous leakage in the corpus cavernosum which is a frequent etiological factor in ED in elderly men Overviews of randomized controlled clinical trials indicate some benefit of testosterone therapy on sexual health-related outcomes; however further investigation in this area is warranted particularly in older men who are not clearly hypogonadal. Long-term follow-up of testosterone replacement in hypogonadal males and a control group indicates that self-assessment of libido was significantly higher in the testosterone-treated group. Testosterone replacement has also been shown to enhance libido and the frequency of sexual acts and sleep-related erections Wang et al also reported improvement of sexual function; however, their data suggest that there is a threshold level of T above which there is no further enhancement of response. On the other hand, Two placebo-controlled trials reported on the effect of testosterone on overall sexual satisfaction, yielding imprecise results. Transdermal testosterone replacement therapy, in particular, has been linked to positive effects on fatigue, mood, and sexual function, as well as significant increases in sexual activity. 1% hydroalcoholic testosterone gel is an effective and safe treatment option in subjects with ED.
Then please explain why it is that I assessed each dose for MONTHS at a time and I feel vastly better on 300mg compared to 200mg. Iāve also tried going higher and did not feel as good. 300, for me, has been the dose that provided the most benefits. Yet here you are claiming I would have been better off going lower. Are you reading this? Iāve done lower. It didnāt work!
It is but I am glad you noticed that, so you can see what kind of dosages we are talking about when we post a study of men on TRT showing all these benefits. We donāt have studies on what your talking about.
Explore that study, it defines supraphsyiological dosages of injections and even tells you how many mg got people there.
I want to take the MINIMUM dose required to resolve symptoms. Iād love for that number to be, say, 100mg a week. It just isnāt the case. Iāve been doing this for years at this point. I have found the best dose for me. Anything higher or lower does not provide the same results. What part of this donāt you understand?
I totally agree with the E2 thing, estriadol is vitally important for glucose metabolism, cholesterol management (look at ones lipids on T only vs T + ai), endothelial function, increased bone density (and maintenance)
As a child with idiopathic short stature I was given anastrozole to attempt to slow premature closure of my ephysical plates, I was given 7mg of anastrazole WEEKLY (the same dose er positive breast cancer patients take!), caused a lot of issues down the line for meā¦ like a loooooot.
If it matters, this particular clinical trial demonstrates a statistically significant difference in sexual function and erectile frequency within people given 125 vs 300mg test/wk, but no difference can be noted within the 600mg group, suggesting a potential difference between differing supraphysioloogic doses, that or the trial is simply too small to come to an adequate conclusion
I know we donāt have studies on supra physiological dosing. Iāve said that over and over. This is SLIGHTLY supra. This is not a 500-600mg steroid cycle. Like I said, you canāt find anything that says it is safe or unsafe long term, right? Howeverxits giving us an increase in lean muscle mass, a decrease in visceral fat, increased cognition, libido, erection strength, cardiovascular health, reduces risk of cancer, Alzheimerās, improved lipids, improved insulin sensitity zetc etc etc. There are only benefits! This is why Dr Nichols and Dr Howell are now doing the research and studies to provide the literature we are missing. For now, my health has improved EXPONENTIALLY compared to just a few short years ago. Tell me thatās a bad thing.
I wasnāt referring to levels, I was referring to the use of aromatase inhibitors. I donāt believe they should be used in a replacement setting unless the individual has a legitimate issue with regard to hepatic function (this impeding normal hormonal clearance), is at a very high BF% (in which case maybe lose a bit of weight, prime oneself for TRT/HRT) or in some incredibly rare circumstance has likeā¦ aromatase excess syndrome. You see guys on like 100mg test/wk and theyāre on anastrazoleā¦ noooooooo
Granted Iām not a medical professional, my opinion means diddly squat
Usually when we give a older guy 200mg a week about week 10-12 he will say he is not feeling as good. Says he was feeling great, but not anymore. They usually try to blame it on estrogen. If you skip dose during the second week you can tell if you are starting to feel better. If so your T got too high and you were getting test flu.
Now you have assessed if you feel better with them short or high in a short period of time where all these other factors are going to come into play.
So we usually end up reducing anywhere from 20-40% and this solves the problem.
I heard people here refer to it as the āTRTā honeymoon before.
Test flu simply is etiocholanolone mediated immunostimulation no?
Iāve seen it on labs with guys on large cycles, theyāre like āahhh my WBC count is up, Iām sick/have cancerā and Iām like ānoooooppppppeā
@unreal24278 there is a point of diminishing returns. Itās a different number for everyone. A nunber where the negatives begin to outweigh the positives. I have not experienced a single negative so far. However, list men would require only 200mg a week to attain the numbers I have listed in my labs. Iām a special case, though Iāve met other like me.
No idea, your probably smarter than me on that. I just see it happening, and much more frequently in the older group. Titration usually fixes it right up.
Younger guys donāt have the same problems, when they first start
Etiocholanolone is an oxosteroid produced via the metabolism of testosterone, causes leukocytosis, fever, immunostimulation and general feeling ofā¦ un-wellā¦ness.
5 days after 200mg sustanon I clock in at 540ng/dl, granted given the shorter esters present (prop, phenylprop) my peak is probably around 1500ng/dl.
@unreal24278 obese men are the LAST ones who should be taking an AI! Why? E2 is directly responsible for reducing visceral fat. Blocking that in an obese man would be nuts.
Yes but aromatase inhibitors only have the ability to partially block aromatase in certain tissues. It does not get down into dense lipid cells, so you still have aroma taking place.
