Ask Physiolojik Thread

Yes :slight_smile: But it is off the record tho…

Quick question, if I add something like primo or mast to combat the high e2 does this work?
Or is it not about the a:e ratio but just the level of e2 (only care about Gyno to be honest, bp and such are always normal)

Well I thought you were quite a bit older, but for 18 year old you do know a lot and seem to have life experience often associated with older people, which is a good thing because most teens are doing it all wrong unlike you and for that I respect you and your opinion :slight_smile:

Next question if you don’t mind…
How come some AAS compounds have high anabolic rating, but are quite weaker in term of putting on lean muscle? For example testosterone vs oxandrolone (100 vs 300+).
Now I’m not just talking about these 2 compounds exclusively, as there are many more examples of this, but just in general.

Animal models demonstrate dihydrotestosterone (and presumably various derivitaves such as drostanolone, mesterone and more) appear to compete for binding at the ER (competitive inhibition), that or interaction with mER (both are possible scenarios), competitive inhibition seems more likely.

It’s about genetic susceptibility and ratio of androgen to estrogen, using mast/primo for ā€œanti estrogenicā€ properties is a bad idea, it’s adding drugs unessecarily. Look at literature using doses of 3-600mg test/wk, although small (sample size wise), one can see the chances of getting gyno don’t appear to be very high.

Granted genetic susceptibility, hepatic function (cyp + p450 metabolism and clearance) and BF% will play a large role.

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Because A/A ratios are based off of rat models, anabolic ratio being calculated via how much a particular anabolic stimulated hypertrophy of the levator ani muscle (in rats) and androgenicity being how heavily an anabolic stimulates growth of the prostate/seminal vesicles of a rat.

Take DHT for instance, rats don’t express 3-HSD in muscle tissue, humans do (3-HSD metabolise DHT to metabolites of which are inactive in muscle tissue), hence the anabolic rating isn’t zero. Other factors can come into place

That being said, oxandrolone isn’t actually a weak anabolic, in terms of pure muscle tissue gained I’d say mg/mg it’s far stronger than testosterone, I can show literature demonstrating low doses of oxandrolone give equal to or greater gains then equiv doses of test (for instance 20mg of oxandrolone / day would equate to roughly 200mg of esterified test/wk (molar mass equation may differ a bit but 70mg pure test = 99-100mg test E/C), look at the data of who gains more muscle mass, people on 200mg test or 20mg oxandrolone/day, ox outperforms test by quite a bit, not exactly 6x (as estrogen has anabolic activity in itself) and other mechanisms such as increased glycogen retention etc arent as strong with oxandrolone, however various mechanisms (nitrogen retention, decreased amino acid breakdown) etc are waaaay stronger with ox

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Unfortunate, but true.

Many teenagers do stupid and irresponsible things, including myself somewhat, but to a lesser degree (for example if I’m on vacation I’ll rent a scooter or motorcycle if possible). Many adults also do heinously irresponsible things. On both parties one could say it comes down to a lack of knowledge or education on the risks/long term consequences (whether it be recreational drug use, risk taking behavior such as unprotected sex or driving dangerously), that being said, a few of the most ā€œexperimentalā€ teenagers I know are actually also some of the smartest kids I know, therefore I think predisposition to substance abuse/risk taking behavior may be somewhat genetic

Youre a boss!
I unfortunately experienced gyno @400 test-e e5d
BF was 14%
I hate AI’s and for me for Nolva to work I need to take around 10mg for every 100mg test-e
Therefore I am looking into new combo’s, did not had any problems with test-e anavar but that was also a low dose of test. Now looking into Test-e + Primo and some anavar as kickstart. Will dose the Test-e around 500 and same goes for primo, anavar will not do more than 50mg…
BF now is also sitting at 10% but I still have a small lump of gyno left from the previous cycles.

Have you ever thought about getting mammary glands removed?

Yes but it is not that noticable… Maybe I will do that someday but at this moment Idc that much about it. But ofcourse I want to prevent it from becoming worse

Nice one, thanks again :slight_smile:
Yeah, I base my point of view about teens being irresponsible on my recruits that I teach and command (I’m team leader in the military or more specific infantry). So seeing you being drastically different and much more intelligent is very surprising to say the least. If I had to guess I’d say you are in your 30’s or so. Keep it going I’m sure one day you will become a great doctor that this world lacks… atleast in my experience.

I’d assume AAS use is relatively common among these individuals given the profession no? Granted a lot of kids will just take whatever

At a house party (I do attend house parties and occasionally, say once every couple months, which is a very ā€œteenageā€ thing to do) about a month ago I met a few bodybuilders (my age), upon chatting about supplements, workout routines and whatnot I come to find one is considering using selective androgen receptor modulators and another knows of individuals (16-18 age range) using them. I quickly explain these drugs are relatively unresearched, but to not come off like an arrogant prick or parent I tell them ā€œif you have to use anything, which I don’t condone at all, at least you know the harm anabolic steroids can potentially causeā€. (In AUS DMZ, a few designers and SARMS can be brought OTC if you find the right store).

Either way was nice to find other individuals (my age) interested in bodybuilding, it’s a rarity (most kids will go to the gym to hit some abs, chest and bicep in hopes of attracting girls… notice I say girls and not women). Unfortunately these bodybuilders appeared to smoke cigarettes, something of which I presume isn’t common in bodybuilding.

Well, a lot of recruits can’t really take AAS unless they hide it somewhere as we do check their lockers and whole barracks often (military police also checks them for drugs and etc. They also bring trained dogs ā€˜german shepherds’ to check everything thoroughly.) I also didn’t mention they are allowed to go home only rarely and on unfortunate situations like death of family members or close ones.
On the other hand we have what we call professionals or more like regular soldiers to understand better, they seem to be not as fit as civilians make them out to be as most are overweight compared to people like us, but some are very fit and it’s unknown whether they take something or not, just like me I don’t tell anyone that I do AAS because of the judgment I would get from others and they would put my hard work on AAS use… Some that I know used for sure such as popular dbol or so (let’s admit most are not man enough to inject their butt) failed miserably and shrunk after stoping, because diet was never in order and training was crappy at best and when dbol gone, no motivation left… lol just like civilians that use something without a clue about how it works and what it does…

@physioLojik I have high e2 (87.5pg/nl) but don’t want to use an AI.

What is the best natural AI and suggested dosage too please.

Shitake/Portobello mushrooms, DIM, warm lemon water, liver detox supps (Curcumin, nac).

Dr Sir is currently MIA (missing in action) for the indefinate future, but will potentially be back, no confirmed date or potential time window for when a revival would occur though.

Are you on TRT/cycle, if so what dose, do you drink, eat badly, what’s you’re BF level, do you eat a lot of processed food or soy products, there’s a lot of variables as to why a certain hormone may be out of whack compared to others.

If you’re T/DHT and whatnot are also high then the high E is to be expected and unless you have HBP or gyno or something it’s not going to pose any more of a threat than having elevated concentrations of other androgen entails, as a matter of fact it’ll even protect against the deleterious effect of T/DHT on lipids.

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Which books do you use to obtain all this knowledge over ASS? If you are 18. REally curious

Unreal is a genius.

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@unreal24278 is fucking genius and he reads medical journals for fun!

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Are you getting symptoms from what you think is high e2 ?

I’m bloated and my dick doesn’t work. It feels numb, hard to orgasm and ejaculate was thick and clumpy the other day.

Also it tastes rancid.

…

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Bro wtf you taste your jizz?

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