How it effects people with differ based on lifestyle, workout routine and genetic predisposition, however staying on for so long puts you at a greater risk for serious adverse effects, it simply isn’t smart to run 500mg for 8 months
The body becomes accustomed to the dose and reaches homeostasis in which AR downregulation may occur (reversible) however this also means gains taper out.
regarding health you might be right. regarding gains - are you speaking from personal experience? I do, and last cycle (6 months on 500mg) I’ve made consistend gains throughout the whole time, also strength stats went up almost the same percentages in the last 2 months as in the beginning. receptor downregulation has never been proven as far as i know, just a total bro thing. of course eventually your gains will diminish, there is only so much you can do with 500mg.
I don’t believe 12 weeks on, 6 weeks off, 12 weeks on, 6 weeks off (total 36 weeks) is more beneficial in terms of gains than 24 weeks on, 12 weeks off (also total 36 weeks).
Hey guys, I’m about at my wit’s end here and need some guidance. I’m experiencing irritability going on 5 days along with depression/no motivation, fatigue and exercise intolerance.
I called Defy up today and I became really frustrated with their suggestions. They told me it sounded like I was experiencing high estrogen symptoms and recommended I take anastrozole. I refused and asked for a blood test to confirm high E2, they obliged. I explained to them that my E2 was 25 the last time I checked and that anastrozole without testing could be disastrous. I asked if I could possibly be experiencing hypogondal symptoms due to only injecting 10mg ED. They said it was possible and that a free T in the low 20’s would be ideal. They then pushed HCG and told me things like “to get your free T up you should really try the HCG.” I mean, this doesn’t sound correct, can’t you just do that by increasing your test dosage? Am I missing something? They also said I could start T3 meds based on my thyroid labs. They explained that my higher-end reverse T3 indicated to them that I was in fact suffering from hypothyroidism rather then hyper.
Does any of this make sense? I’ll have my lab results tomorrow and I can post them. Here are my last labs on the aforementioned systems for reference:
Thyroid:
Reverse t3: 20.7 Range 8-25
T3 free: 3.7 Range 2.3-4.2
T4 free: 1.77 Range .89-1.76 HIGH
TSH: .536 Range .55-4.76. LOW
Thyroid Peroxidase abs: <28.0 Range <60
Thyroglobulin abs: 23.4 Range <60
Endocrine:
Total Test: 527 Range 229-902
Free T: 16.4 Range 4.4-16.8
E2 Sensitive: 25 Range 0-40
SHBG: 13.7 Range 14.55-94.64 LOW
Over time to seek homeostasis the body will desensitize androgen receptors, much the same way the body does with dopamine receptors to addicts on cocaine or insulin in diabetics.
Update: E2 came back at 45, that explains this horrible depression and lack of motivation. Should I be skipping shots to bring this down and how quickly will that work? If I call Defy they’re just going to tell me to take the anastrozole I have on hand.
If anyone could help out with this I’d be grateful. I have a very long week of work starting tomorrow and I can barely function.
How long on this protocol?
8 weeks this Thursday on 10mg ED.
I mean at 527 you may still be suffering from low T symptoms I imagine. Has there been talk of increasing you dose over 70mg a week? Maybe with a higher total T you will feel better. Just thinking here man.
I hear you man, I was thinking of increasing the dose but that E2 reading made me pause on those thoughts. The labs for test and E2 up there are about a month old. I actually haven’t received my free-T and total T readings from today, I’ll most likely get them tomorrow.
As far as increasing the dose, wouldn’t the E2 just rise more with the higher test levels?
45 isnt crazy high. Maybe the ratio of e2 to estrogen is the issue? I’ve been higher than 45 and felt great but my tt was closer to 1000 ng/dl…
I had pretty severe symptoms once when I was at 967 TT with an E2 of 47. That ratio gave me severe panic attacks but right now it’s crippling depression. For a few days before this it was extreme irritability. No idea if it’s my low shbg making it affect me like this or what.
It also makes no sense to me why my E2 is this high while my dose is low. I haven’t received the TT and FT results yet but I’m sure they’re not anywhere close to the 900’s. Obviously low-dose ED shots are not working for me even though I have low shbg. No idea where to go from here.
Yeah the 967 and 47 are good numbers. Nothing wrong there. You have other problems
Just food for thought. You are getting pretty good levels at 70 a week.
Did you ever try something like 40mg 2x a week?
Not to confuse you more. Cypionate at Ed makes no sense to me.
I would not even take 1 ai pill. If you want to lower the estrogen which you may not have to, you can inject 6mg for 2 days. Just saying
Not yet, since my last 200mg every other week failure (terrible protocol, I know) I thought I’d go the exact opposite direction with lower doses more frequently, looks like that isn’t working either.
Not confusing, I know with the long half-life it almost doesn’t make sense, but I figured I’d try the more frequent, lower doses since my shbg is so low. Looks like my answer is either somewhere in the middle or entirely in a other area altogether. I’m pretty discouraged at this point and wondering if I’m going to end up on an AI eventually. I really don’t want to take one but my body seems to convert at such a high rate.
This is frustrating. You are getting closer to what you will need…
I went through the same shit.
Injecting ever 10 days. Than 8 . Then 7. Felt good at 1x a week. But kept reading 2x a week is better so that’s where am at . Played with very low dose ai that put me on rollercoasters. After I stopped ai and did same protocol for 2 months I felt stable
Dunno how you did this with kids man, it’s insane. Mine is due soon and I’m freaking out. The way I present on this forum when I’m having hormone issues is very unlike my real-life persona and that’s frustrating to me. I’m a strong willed person but these hormones reduce me to a whining child.
Anyway, thanks for the words of encouragement. When I was on eod shots my E2 only rose to 34. The question I’m asking myself is if I’d remained on that protocol would my E2 have continued to climb anyway or did the new ED protocol mess me up.
So Dr Sir. I have the ability to legitimately get a prescription for various peptides and even SARMS if I so choose. In you’re professional opinion, is it worth going for the script or should I simply leave it. Granted I certainly don’t require these extras in order to make accruations in muscle mass, the fact that I’m able to get these prescribed with associated close monitering and supervision from a medical professional makes me quite comfortable with the idea of said peptides. Granted these substances very well may not be safe. The peptides I have available to me are
The way I see it, use of GHRP’s would very likely exacerbate any existing LVH that I could potentially develop over the next few years. Aside from that the major concerns appear to be
I apologize if this post comes across as if I’m being irresponsible, that isn’t the intention, I’m simply looking at various options I have and weighing the pros and cons to see whether said options are worth it. I’m aware these are relatively new, unresearched chemicals. The peptide I’m most particularly interested in due to potential cardioregenerative abilities is TB-500. I’m not in a rush/hurry, nor do I need/ have a particular urge to start shoving peptides into myself, however the concept of peptide therapy in itself is rather interesting.
I’m not looking for a seal of approval or something along those lines, however I do wish to know you’re opinion on the topic (the only reason I’d even consider this is due to the fact I’m able to get a legitimate script + monitering.)
Interested in his opinion on ipamorelin as well.
So why fuck with these chemicals?
At 18 I imagine with proper testosterone levels you can bodybuild pretty good.
You see all these issues guys have when they take these exogenous chemicals.
You talk about the affect of weed under the age 21 in a developing body…mmmm
how would you then structure an optimal off-season/prep to gain mass? let’s say the offseason is from october-april (7 months), cut for contest 3 months (mens physique) in july = total 10 months, after that 3 months cruise till next october.
I’d be on for the whole time, but just with a moderate dose of test (500mg). I’m making consistent gains and can also hold the mass in the cut on that.
Would you rather say: just bulking for 4 months (october-january), then cruise till april and then again raise the dose for the cut?
I’m not willing to add in other compounds (other then mk677 which I’ll add soon), because I believe I can reach my goal with test only, no need to experiment with other AAS (also I’m getting everything from the pharmacy, other AAS would need to come from UGL).
I’m now on month 5 with 500mg, had bloods done this week and everything is still well (HK 0.48, LDL 68, HDL 46, CHOL/HDL 2.8, GGT 16, HBA1c 5,0, blood pressure 135/80, prolactin 11).
My E2 is 62, I’m on a small dose of arimidex (0.25e3d) to no let it get too high but still have a good level (as its also anabolic and I feel fine on that level), I sometimes feel a tingling sensations in my nipples if I skip the arimidex.