@unreal24278 you’re awesome man. But you worry way too much about way too much 
your dosages are fine.
Tis in my nature to worry about things #anxiety, I’m aware I get overtly worried about things that aren’t a big deal, I mean… It’s not like I’m on 2 grams of test a week, and even if I was it still probably wouldn’t kill me. I tend to get anxious about things and then I eventually stop to think about it and I’m like “wait, why was I anxious about that” and then I get anxious about it again a week later hahahaha. Hence why my decisions about stuff tend to flip flop quite a bit. Everyone has their issues, some people (like me) just have more issues than most people, however with as many negatives as I have there’s quite a few positives (high intellect… Um… No that’s about it) wait… The ability to retain movie trivia, does that count?
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“To identify agents potentially useful in protecting against TMX-induced toxicity, we screened the NINDS-II library of 1040 compounds containing drugs approved for human use or in clinical trials. O-2A/OPCs exposed to 1 μm TMX for 48 h, which killed >80% of cells, were also exposed to NINDS-II library members at concentrations of 1 μm. We found 27 compounds that protected against O-2A/OPC cell death, in some cases providing almost complete protection. Not surprisingly, treatment with multiple estrogen analogs prevented TMX toxicity, as shown for β-estradiol, which reduced the proportion of PI+ cells by more than half (Fig. 2 A ). Protection also was provided by the antioxidants α-tocopherol and resveratrol, and a variety of other substances.”
Hi @physioLojik, fairly new to this website, thanks for taking questions.
I had one regarding some blood results, specifically the following:
MCHC - 30.8 Ref Range: 31-37 LOW
MCH - 26.7 Ref Range 26-34
RDW - 16.2 Ref Range 11-15.5 HIGH
During a consultation with Defy Medical I was told the aforementioned results could indicate a GI bleed. They asked me to follow up with my PCP and possibly have a stool test. I did so and my PCP said those ranges don’t bother her. I know the ranges aren’t exceptionally out of range. However, my MCH and MCHC have been somewhat low or on the cusp of low for a couple of years.
Should I be demanding the stool test or should I just accept those ranges as is? My PCP also told me my total T level was fine in the 250’s because it was within the reference range, so I’m wary of her.
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So easy to do. I would request this anyway. It’s pretty standard.
Right? My PCP often ignores things that are easy to do. I’m currently searching for a new one.
When Drs says not necessary you say I would like to do it anyway just in case. And insist if still says no.
Ik some mds won’t have it. I have a Dr that will order anything I ask.
If you go to a gastroenterologist their will do a colonoscopy. Any hint of blood or possible blood in stool they cover their ass. Plus easy money for them
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My Dr has a bit of a god complex. I usually ask for the NP she works with but she’s currently out on maternity leave.
I think you’d have to take a lot lot lot of Tamoxifen to reach a concentration of 1 micromolar, although I could be wrong. 1 micromolar is 1000nmol. It’s like that study that came to the conclusion testosterone and stanozolol kill more cardiac myocytes than controls when left ventricular myocytes (rat left ventricular myocytes mind you) were exposed to concentrations above 10 micromolar. And I’m sitting here thinking “either the drugs are reaching different concentrations in different tissues or they’re just trying to find issues” because it’s almost impossible for a human to take enough testosterone to reach a BLOOD concentration of 10,000nmol on a blood test.
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Interesting and thank you for the response. I read the articles but I dont fully understand how it ties in to bodybuilding uses. That’s why I’m asking questions. I see guys talking about “brain fog” due to tamoxifen and fearing permanent brain damage. I know I cant afford brain damage.
Skin Cancer in Australia, it is pretty high. Alternatively many people aren’t getting enough vitamin D because they are always wearing sunscreen and avoiding being in the sun.
So much of getting skin cancer is about exposure to sun, as well as genetics. Gen X are the last of the people from the sunbathing era where getting sunburnt was just part of summer.
Subsequent generations like yours are less likely to get skin cancer because they are more aware of the risks.
The majority of skin cancer is due to inflammation just like any other type of cancer. Work on combating that and cancer has no chance.
@unreal24278 is right. The dosages aren’t even close to realistic. Also myelin is close to my heart - I have multiple sclerosis personally. Diagnosed well before AAS use. I wouldn’t take anything to mess with that.
You have MS?
@flappinit yes sir relapsing / remitting. So far not too many issues
There is now ample evidence that proper diet and exercise can reverse symptoms of MS. Of all the things to mention about yourself, that is particularly significant and I applaud your obvious drive to live life in spite of your situation. Knock em dead, dude.
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@flappinit thanks man. I never want to ever come across as a victim or a patient haha. And yes - diet is HUGE for MS. As is training as you mentioned. I have a kick ass support system as well - my wife is amazing and knows when to be compassionate and when to really kick my ass haha!
Thanks again man. Your words mean a lot. I have a hard time with people who come up with excuses for why they can’t do things.
Funny story - when I told my wife (who was then my girlfriend in med school) that I had MS she chuckled and said “well, we all have things to deal with and you are the toughest guy I know so it’s an equalizer. Plus, one day I’ll be able to kick your ass - but that day will be really far away.” At that moment I knew I’d marry her. Ok sappy story done.
For all you tough guys out there - don’t forget to bear your soul and heart to a good woman. Support is the best thing for us.
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@jpt365 request a referral to GI. Probably nothing but better to check. Always.
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Funny that we talked about marijuana not long ago. I’m always hesitant to defend marijuana because despite using it for anxiety relief, I know that most people use it exclusively as a recreational drug, and drum up every obscure defense they can think of to advertise it to everyone. Weed affects different people in different ways, and some people will experience nothing but adverse effects from exposure to it. However, if we’re talking MS, marijuana is conclusively significant. MS patients go from non-vocal to borderline talkative within minutes of ingestion. Same with Parkinson’s. It really can be an incredible drug in the right circumstances.
that’s… quite something, I’m sorry to hear about that. I applaud your (from what I’ve seen via your posts, although you could be different in person) positive attitude and general happy vibe, I don’t know how you do it. You said you don’t want to be treated like a victim so I don’t know what to say, as medicine progresses we might have new therapies/ treatments for MS. Immmunosuppressive drugs suck (side effect wise), so do corticosteroids, idk if you take them, but I know they’re used for treatment of MS, anabolic steroids are also probably helpful to some extent (myelin sheath, androgen receptors yadayadaya and so on)… Does it impact you’re training???
May I ask why you personally don’t like anavar, you said you never got anything from it right, and I took it once for five weeks a while ago and once again for a much shorter period of time (sub 1 week) then stopped (wanted to see if it was actually the var causing HBP, yes it was), anyway I noticed that it made me much harder, vascular, gave me amazing pumps, made me strong too (and it made me strong fast), weight felt easier to lift off the ground. Granted everyone responds differently, and it was clearly very harsh on my body given the effect it had on my BP. But I started noticing these benefits at just 12.5mg/day, and at 25m/day the effects were amplified even more. So do you just not respond to it or something? Because for me it’s hands down the most effective (and harsh) drug i’ve ever taken with regards to bodybuilding, it’s effects were awesome but due to the effect it had on my BP and (likely lipid profile) I’d say two thumbs down, wouldn’t do again.
I’m curious, do you smoke marijuana or use it through other means (edibles… creams, vaping, etc etc.) Does smoking weed harm the lungs, irritate the throat like tobacco does? I’m not experienced with marijauna however when I was like fourteen I smoked a cigarette and I tried marijuana once, Marijuana didn’t irritate my throat much at all, the cigarette made me want to throw up. Haven’t touched stuff like that since because why would I ya know. I’m super anxious all the time, I can only imagine marijuana would make me super paranoid, and the potential psychiatric effects of the drug scare me.