Anxiety In my First Week of TRT

Pharma TRT
1

Hi guys,

Long time lurker here. 34yo male. Have been experiencing symptoms of Low T for a few years and after trying optimizing lifestyle (diet, supplements sports, reduce stress, good sleeping habits) these symptoms kept getting worse. Amongst others decreased libido, fatigued, anxiety, brain fog etc,

I started 90mg Test Cypionate (subc) per week pinning with an EoD protocol. I am also on HCG 1000iu per week (also pinned EoD).

I suffered from mild anxiety before starting TRT, but on the day of my first injection I felt my anxiety going up significantly. The last few days I have been quite anxious (less on in the afternoon/evening of the day after my injection) and I am a bit concerned that this will grow into a anxiety/panic disorder.

Any advice on how I can best deal with this? My temper/anxiety when heightened are no fun and challenging to power through.

My bloods before I started TRT:
Test total: 13.7 nmol/l (395 ng/dl)
Free Test: 0.291
SHBG: 27.3 nmol/l
Estradiol: = <0.09 [ref range = 0,09 - 0,128]

2

I don’t believe there is any chemical mechanism of action that would cause increased anxiety issues on the very first day of your very first pin of test cyp. It’s just too short of a timeframe for anything to actually occur. It’s likely a psychological issue related to your previous (un)diagnosed anxiety issues.

3

How nervous/anxious were you when you took the injection? You did it yourself?

4

The hCG can cause a lot of side effects, anxiety being one of them and HCG often ruins the feel good effects on TRT. For most there is a price to pay to maintain fertility on TRT. Sub Q injection is overrated, and the vast majority of men feel better injecting IM.

1 Like
5

I know my body/mental state quite well. There was significant anxiety that was not psychological induced - I am almost sure the Test C played a role, despite it being the first time and a relatively small pin.

6

The anxiety on the test C started c. 6-8 hours after the injection. The HCG was not part of the pin the first day (as I was traveling home from the clinic by airplane and did not want to open the HCG until I was home).

7

Not nervous at all. Was happy to start pinning after all the research I did and meetings with the clinic I had. Was in quite a positive mood before and during the pin.

8

You may be a bit sensitive to the androgens is all, if this persists just inject smaller doses more frequently.

9

so same weekly dosage, but every day pin right?

10

I don’t think frequency matters much but dosage matters a lot. I’d try dropping the dosage down to 60mg which should put your average Testosterone level in the mid-range and that should help with anxiety.

Here’s a great little paper showing how little testosterone is needed.
Sexual function does not change when serum testosterone levels are pharmacologically varied within the normal male range - PubMed.

12

That’s an interesting approach. I’ll try to lower to 70mg and see if anxiety lowers.

Regardin pinning frequency, is it not the case that every day/EoD pinning reduces the fluctuation over time of the test in the blood?

13

Personal opinion here but from listening to doctors like @highpull I believe the body has ways of kind of evening out the highs and lows and the average level is more important. I’ve had blood work 4 days after my shot and I’m at the top of the range. I’m doing once a week shots and I have a test scheduled for December 1st and I’ll find out what my trough level is. I’m anticipating it to be pretty low but I don’t think it’s a problem to be at the bottom of the range for a day or two. I think, at most, you only need to do 2 a week about 3.5 days apart. I personally do once a week for the convenience.