Anastrozole; to AI or Not to AI, That's the Question?

Pharma / TRT Testosterone Replacement
1

40y old male here. I’m currently 2 weeks in my TRT protocol of 0.25ml E3D of Sustanon 250. So i’m pinning around 145mg/week.

Before i started my TRT i had some very smal and very old lump under my right nipple. This was some old gyno remnant from a Test/Dbol cycle from ‘back in the days’ (sigh, yes i know…)

I noticed last 2 days the lump became sensitive. I can’t tell if it grew or not, but it feels a little bit like a small bruise. Not extreme, but it’s there.

So, i’ve looked into Anastrozole and found this study. It seems to effectively counter high E2/Gyno while not interfering with TRT.

I have some questions;

-Besides the literature, are there ppl here which have used both TRT with- and without Arimidex/Anastrozole and did you notice (besides lower E2) any deminishing ór enhancing effects of the TRT?

-I know E2 is important for us males for libido and hearth health so i don’t want to crash my E2 into the ground, but just enough to stop gyno from furhter developing. What is a good, small dosage, to start?

-is it smart to even take Anastrozole at this point, or should i just wait it out so my body can balance shit out on it’s own?

2

This…

I would suggest taking AI when you actually feel the symptoms. My e2 can be in many hundreds and i dont even bloat so i say - fuck it. Most people are more sensitive but i wouldnt suggest taking AI before you really feel that you need it.
Anyways, crashing e2 is not that big of a deal if you are on test, and maybe even e2 sensitive - it should get back to normal pretty soon. Anyways you can always pop a few d-bols and skyrocket it back up, haha.
As far as the lump goes and it being more sensitive - sensitivity wouldnt be the reason to take AI in my book because it might go away, but check the lump and see if it grows. If it does, maybe it would be worth to cut it out? I mean, taking AI just because that 1 thingy hurts is also not too cool - you probably should just get rid of it.
At your test doses, most people do without AI their whole life.

tl:dr - give it some time, and just make sure the thing doesnt grow.

1 Like
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Love your name, a Dutchie too like myself?

Thanks for the input. I’m not afraid to get it cut out, and the money isn’t a problem either.

Just don’t want to take medication while i don’t need it.

I’ll give it some time, but i’m not sure if hurting means growth gyno whise. I cannot see it, i only feel.

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AI can save someone’s TRT experience. I use it.

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I had small gyno before starting TRT as well. About a half marble size lump. When I first started and/or made a protocol change I would get flare ups too. Eventually that went away without an AI. I would give it a few more weeks before jumping on the AI if thats the only symptom you have. If it gets worse or doesn’t resolve after a month, reconsider. Just my two cents.

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I wouldn’t do anything this soon. I found this line pretty revealing tho:

“1708 men with TD were placed on TTH. Of these, 51 (3%) were treated with AZ (AZ+). After exclusions, 44 (2.6%) had elevated estradiol levels >60 pg/mL or >40 pg/mL with symptoms“

Out of 1700+ subjects only 100 met the elevated e2 requirements. So an AI isn’t something I would say is commonly needed while on TRT. Your experience may be very different however. I’d get lab work at weeks 4-6 and match with symptoms. Go from there

Edit: sorry, I read that wrong. It’s 51 men that had e2 higher than 40pg/mL. I added the two groups together

7

Personally id try and get dialled in without one for a good 6 months first.

Use tamoxifen to counter gyno in the meantime if thats the only issue.

If after 6 months you cant get dialled in as e2 is causing issues then try a small amount.

That was my approach. I also use sustanon e3d at 0.25ml. Works well.

I don’t need a lot of anastrozole but a little (approx 0.25mg once per week), helps me.