Always Tired Again

There are different problems of that nature. The body shape might not be a perfect fit for that. This is clearly a case of primary hypogonadism which is a hallmark of Klinefelter’s, the testes do no work and that requires TRT unless there is bilateral testicular vascular abnormalities that can be surgically corrected. Given history, that seems remote.

Suggest that you get semen analysis to see if you have any fertility to protect.

E2 seems a bit high VS FT level.

TSH should be closer to 1.0 and you have not discussed your history of using iodized salt or selenium or posted oral body temperatures. This could be a major factor in your low metabolic rate, fatigue and tendency to get fat.

fT3 is the active hormone and is well below mid-range. fT4 is a bit low too.

Do not even think about IR without first addressing selenium history and supplementation.

CRP is a generalized inflammatory marker. Anything sore or inflamed?

You probably would not have absorbed androgel.

Your problem is doctors. There is a sticky for that.

Where are you located?

Labs on TRT: How long on that protocol for the labs?
If protocol is effected, we expect LH/FSH–>zero.
So something is not right. Hypothalamus seems to be telling pituitary to produce LH/FSH when it should not. Seems stuck. Monitor in future. In this state, you do not need any hCG. May need an MRI to resolve if this persists.

E2 is horrible. You need a different doc who is not ignorant. You are at risk if gyno and this is also hard on your brain, mood, prostate and arteries.

Use anastrozole. It has no direct negative effects on lipids. When you read about such things it is in the context of doses that produce very low estrogen levels and we are not doing that, we are modulating E2 levels to a more favorable normal level. It is very low estrogen levels that are the risk, not anastrozole itself.

Please read the stickies found here: About the T Replacement Category - #2 by KSman

  • advice for new guys - need more info about you
  • things that damage your hormones
  • protocol for injections
  • finding a TRT doc <<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<

Evaluate your overall thyroid function by checking oral body temperatures as per the thyroid basics sticky. Thyroid hormone fT3 is what gets the job done and it regulates mitochondrial activity, the source of ATP which is the universal currency of cellular energy. This is part of the body’s temperature control loop. This can get messed up if you are iodine deficient. In many countries, you need to be using iodized salt. Other countries add iodine to dairy or bread.

KSman is simply a regular member on this site. Nothing more other than highly active.