No not yet.
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Ok, I saw a study that it takes a while. But they did only measure a few days after continuous GH application so I donāt know when production is expected to come back. If youāre getting blood work, Iāll be there to tap on the heart button if you post it 
Thanks for the responses guys. @lordgains. I will write back at your long post when i have the time, thank you!
I just came here to say that i injected my first Hcg dose just now. 250iu. Just for the record:
I mixed my 1500iu powder of HCG with 1ml of %0.9 sodium chloride containing bacteriostatic water. Then i took that solution and added to an another vial which contains 5ml bac water again. And then i took 1ml from that final vial and injected it to myself from 2 inches near of my belly button. Injection area slightly burns and i felt a warmness, thats all. 6th of 1500iu= 250iu. I hope the potency is not affected because i mixed it with more water than usual. (?) Now the perforated vial is in the refrigerator but not in the fridge. I hope there is no air intake due to needle holes, i covered it with tin foil tightly.
I will do a bloodtest after a month to see my E2 and Free T levels. Will use an AI if it is needed. The major reason why Tamoxifen didnāt work for me was that my Free T didnāt change, i hope i can break that issue with HCG now.
What can i say, i hope everything that happened to me was a part of Godās plan and that i may finally deserve to see the light in near future. Fingers crossed. 
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What was the total volume of liquid added to the 1500IUās of powder?
What volume did you inject?
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I thought i clearly stated every detail about what i did in my message, lol, no problem.
I added first 1ml to my 1500iu powder. And then i added that mixed liquid to an another vial which contained 5ml of bac water. And then i injected 1ml from that. So i divided it to 6. Now the vial contains 5 doses.
Just making sure because itās an odd way to do it.
1500IUās/6ml=250IU/ml. So 1ml or 1/6th of the total would be correct. I wouldnāt be afraid to double that dose, 250IUās is on the low end for sure, but some people do fine there.
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Anyone knows a proper and safe AI dosage? I have Aromasin 25mg. Some people take 1mg once a week! And some recommend 12.5 mg eod!
This is a pretty mysterious topic on the whole web. I planning to take a little AI to see the if it will make any difference. Are there any risks?
Because my E2 was high even on low dose Tamoxifen, this HCG will probably rise up my E2 more. Took my second dose today, no changes yet.
Donāt take the AI for prevention! Only if you got symptoms and blood work to confirm.
Small doses, 12.5 mg once (not EOD) if you got symptoms.
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I couldnāt have time to read the study and i try to stay away from forums and articles lately.
My professor endo said the same to me. But then, if this is the case, how we can explain PFS or PAS? Epigenetic changes? Why body would do this to itself?
Can you explain all of this very simply and minimally if you could please? I really donāt understand much and this confuses me.
But what does this exactly mean? So is there a chance that PAS supressed my particular ARās at genomic level!?
Or supressed some genetic traits that i would have if i never took this poison?
Via CpG hypermethylation? And most important, does these epigenetic changes mean it happens on the whole body, or the targeted tissues?
Earlier you also said smth like āāI didnāt particularly fucked up with Androgen signaling- transcription via Accutane so i have more luck that my development didnāt have any damage.āā Then why i have low T symptoms?
As i suspect, maybe this methylation occured only in my Prostate? My dad has prostatitis and my grandfather has prostate cancer! So maybe PAS triggered some changes only on my prostate?
I know epigenetics are reversible, so if i reverse it by recovery, i should express my full genetic coding regardless of my current age, right?
Secondly:
https://academic.oup.com/jcem/article/87/8/3573/2846550
After reading this study, i think im going to start HGH eod today. 1-2 iu. Would this supress my natural secretion after treatment?
In the study the dosages and usage times were so different, i canāt compare it with my low dose. But i guess even 2 years of EOD caused only 0.1 difference than P value then i should be safe? Btw, does P value means, their natural growth rates before treatment?
Thanks. (No drastic benefits from HCG yet, but im hopeful.)
(PS: There was that FoxO1 study about Accutane, there are 3 more similar articles like this. It kinda explains FoxO1 and how it supresses GH at genomic level etc. But my acne didnāt change at all after PAS so i assume PAS didnāt damage my GH. Isotretinoin and FoxO1 - PMC)
A lot of questions again, when you have time please, thanks.
It works like this.
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There is an AR in the cytosol (water in the cell), it gets activated by AAS
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It sets itself free from proteins (called HSPs) and travels (trans locates) into the cell nucleus
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The AR has a region which binds to the ARE, a segment on the DNA
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The receptor binds cofactors for transcription (depending on cell type, these are different)
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The genes get transcribed (for example for muscle proteins) to mRNA
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The mRNA gets translated into proteins
The androgen receptor itself is a protein. It gets destroyed like any other protein when itās dysfunctional and then new AR gets synthesized.
What isotretinoin (or retinoids) does is, it interferes with step 4 and 5 as itās receptor can bind other receptors.
What can happen is, through retinoids the expression of genes can be changed permanently as the regulation cascade changes when you block these steps. Cells are 24/7 fine tuning these cascades so the cell can switch off and on genes through other ways. One way is, than the cell can change Step 1 if it inactivates the gene for the AR, so there is less AR. It can also interfere with Steps 3,4,5 and 6. So when you interfere with the signaling cascades, the cell reacts with different mechanisms. One can be methylation of genes to shut them off.
In the case of accutane most people want that as the acne doesnāt come back when treatment is stopped.
With some people acne comes back when they run a steroid cycle.
Yes. The body canāt change its genes but it can change which genes it expresses. Epigenetics is called that way because it is āon topā of the genes. For example how the DNA lies in the cell. Is it straight, is it curled up?
Maybe.
Target tissue, every tissue can react differently.
Thereās a lot of reasons you could have. āLow T symptomsā is so unspecific that only men over 45 normally get tested for it, as there are a lot of diseases which can cause these symptoms.
They are, but if they happen is another question. And if YOU can change something about it is also another question.
No scientific answer but anecdote says no.
Go to the HGH thread.
My man. P value is a measurement of statistical value, an error measurement. Has nothing to do with the numbers.
Iāll take a look at it.
You are making this too complicated. I hope you really stay away from more input.
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I love the study you send! Really cool stuff.
It explains what I wrote above in more concrete complicated terms. It also connects the dots between AR, IGF-1, GH and insulin. At least it provides some opinion on it.
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He wonāt. Heās been obsessed with his height and whatever else for years across multiple forums.
Is that so?
Heās on another thread right now asking if proviron will increase the size of his penis. Seems like this entire thread has been him asking for advice then he suggests taking a drug, Then he gets more advice and decides to try another drug and anotherā¦
Not sure if he is actually trying to fix his issues or just experiment with drugs. This thread is all over the place. Youāve been giving him great advice and going out of your way to post detailed, long responses and it appears he doesnāt listen but asks what he should take next.
I think he needs mental help for his issues.
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Yes, 100%
Well yes, but i donāt understand why you had the urge to mention this? @ncsugrad2002
Do you know how traumatic and painful for me to experience PAS at the age 16? What is wrong with being on multiple forums? I am aware i have OCD. Thanks to this disease.
But do you know how many people i helped? Do you know how many people i prevented from possible suicides with my detailed data on recovery stories on being multiple forums?
@s.gentz If you are not willing to help others please stop discrediting people. I am trying to RECOVER. Thatās why i try drugs. My penis shrank an inch dude. Do you know how traumatic is this? Do you know how it feels you wish you were dead every morning when you wake up? I canāt even experience an orgasm anymore man. I have the libido of a 60 year old.
You have no idea how crazy PAS or PFS is. Your comment is very rude and lacks on empathy. How do you think i will recover myself without experimenting? Read about PFS. And also i followed the advices here if you read it again, i think your comment is misleading.
@lordgains Thanks a lot for your answer again. That meant a lot for me. 
One more little thing, is this study also applies on me? I mean the bad effects of FoxO1 on GH and Igf-1 became persistent on me due to PAS? I donāt experience any low GH symptoms either.
I think this study and effects of FoxO is only current while you are taking the drug, right? So it is temporary?
As i said my acne didnāt seem to change too. And i also take Accutane for only 3 days. God damn these pharma monsters in eternityā¦
PS: All of this data about genes seems scary, but the funny thing is, i have a friend from same country. He is PAS. We have almost identical symptoms. Someone else said this too, that his PAS completely got cured by smoking marijuana. His penis grew back instantly, amazing orgasms, erections etc. A lot of people experience these, as i conditioned myself to gather recovery stories for years across forums. Instant temporary fixes with various supplements. Even a PFS guy said his adams apple grew back again within a day. They all swear it was a 100% fix on all sides. But they went on sick mode again after short time.
So what im saying is, if the issue is on the genes, i donāt think this could be possible, that prostate inflammation would clear itself instantly, epigenetics will reverse back instantly and then crash again after 1-2 hoursā¦ ?
Sadly, marijuana only increase my libido a bit, no changes on other sides. This disease is truly beyond insanity, lol.
I will report back if anything happens. Goodbye for now!
Yes you are kind of right. Genes donāt change. The way they get expressed changes.
I donāt know about these cases, it sounds very very suspicious. 1-2 hours cure with no effect at second exposure? That would be way way down in the ranking of the quality of evidence.
But you are right in that even epigenetics would t be fast enough to change in that time frame. If itās nearly instantly, then it must be a pathway which is fast and no nuclear pathway. But if itās in 24 hours, then genetic pathways like nuclear receptors are likely.
Iāll check the study out in detail and write what I think.
Did you think about the points I made above? What you can and canāt fix or what you should focus on? Iām really trying to help you but itās difficult. I can see why other members get frustrated reading this. I know itās a difficult fate that you must bear for now but I think you should focus on the things you can control and then you can do some research, if you got the time. But donāt ask the same thing over and over again. Iāll discuss studies and other stuff with you willingly.
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Hi, a quick update for now, HCG seems to not work on me. I also cycled 2iu of HGH, again didnāt see any benefit. I see zero increase on my testicle size and there is no other improvements. Mentally, with the help of Welbutrin im finally doing fine. Anxiety and OCD are nearly gone.
Im running out of time, i need to end this as quick as possible, as also some other people suggested i am now thinking to add Testosterone (Nebido) to my protocol. I have never thought in billion years that i am going to inject Testosterone myself in future, feels like a dreamā¦ But here i am, shit happens i guess.
The thing i wonder is the dosage and the duration of my TRT.
Also, i donāt want to shrink my testicles further, i hope HCG can prevent this 100%? Or i should expect a shrinkage a little anyways?
What i need:
- To fix my symptom permanently and fully* after quitting TRT and HCG, and regain my testicle size.*
- I donāt want to be dependant on TRT, very scary, so i donāt want to mess with my body further.
- I need a small but effective TRT cycle to test my body.
- To create a smart plan of the TRT dosage and duration of use.
I have talked with a Post Accutane victim recently, he studied epigenetics and genetics for 5 years to solve and understand his issue. He knew a lot and explained to me how Accutane, could have damaged the Androgen Receptor transcription or sensivity on epithelial tissue of my body. He also said it is very likely that PAS only affected my prostate tissueā¦ I was very happy to hear that. Still i am.
He says that TRT can work if there is enough receptors on my Prostate. So i though what are the possible properties of TRT on āāAR healing.āā A quick research gave me this studies:
One more thing, Trestolone. A guy on propeciahelp was unresponsive to his TRT protocol and then he added Trestolone to the mix. Within just a few days he says, he recovered fully.
After this event, this time a credible, long time user in the forum who were using TRT that time, also added Trestolone cream to the mix, and he took it for a week and then quit. After cessation, he reported he experienced the strongest erections he ever had since 15 years of PFS. And that improvement stick with him!
So since i have accsess to Trestolone here too, i am thinking to add it just for a week if TRT feels underwhelming. I know this is a highly supressive and strong steroid, so im scared shitless.
But if it is possible to recover my HPTA with PCT after this, i think i can try this. We know something is way wrong with our receptors and Trestolone is the strongest anabolic- androgenic AR agonist out there, it kinda makes sense.
@lordgains What you think about all of this? @iron_yuppie I think you use TRT too right? You should know how TRT works i guess.
Here is the prescription information that my Urologist gave it to me, months ago:
Nebido 250mg/ML Vial 4 ML Everyday 1x1. Intra Muscular.
Seems like a bad protocol to meā¦ Should i get an another version of TRT to treat my ARās, is Nebido bad for my situation? I have accsess to steroid sites here, they probably have it. But it is better to use legal prescription and pharmacy.
I also got Covid, and i was sick for the last two weeks. I still canāt taste or smell anything. I went down to 78 to 71 kg. So i added Mass Gainer and more Carbs into my diet. I hope the sugars wonāt hurt the process of healing since sugar causes inflammation in the body.
Thank you for the help. I hope i can finally beat this.
One more thing, a guy on another forum who helped many PFS and PAS cases recommended me Dexamethasone as an alternative option. I know 2 PSSD cases who temporarily recovered with Dexa and 1 PFS case. Here is his explanation about Dexa and PAS:
**Accutane is vitamin a active. Which hits rxr receptor. Rxr is coupled with thyroid , lxr, vitamin d receptor.
So i assume hitting rxr excessively would downregulate lxr, thyroid and vit d receptor
Androgen receptor gets downregulated with not wirking thyroid lxr and especially vitamin d.
Androgens block vdr, so if vdr is weak then i assume androgens will be lowerd and downregulated
You need to upregulate rxr receptor plus upregulate all other receptors.
I think it can be done with dexamethasone cycles. Dexa will upregulate rxr, upregulate ar, upregulate vit d and thyroid receptor.**