Any of you guys on TRT have an issue with Adex not being strong enough? At 2mg a day it will only take me to the mid 30’s. I may try low dose letro.
Before TRT Adex would run my E2 into the ground. On TRT at 140mg a week my E2 is always high while my free T is upper normal range.
i know it takes a while to achieve baseline serum levels, but my e2 was at 70 prior to my guy introducing adex and after a few 0.5mg doses, it measured 64 lol
If I had to guess I would say that it means there is something else wrong with your system that you are not addressing.
I was on 2mg Arimidex at one point along with 200mg T-Cyp weekly to get me down to 20 E2. but now I am back to .25mg Arimidex daily or EOD. I was able to lower my Arimidex dose once I lowered my T dose and started fixing my Vitamin D, ferritin, magnesium, and cortisol + I stopped my extra DHEA.
What else are you taking and what were your last blood test results?
PM me and let me know your source for the anastrozole, how old etc.
Product lists 1mg/ml or 0.5mg/ml?
Any crystals in the bottle? Use a small flashlight.
I thought it may be the product to but I’ve had the same results with script Adex. On TRT it just isn’t strong enough. When I used it as a standalone treatment my E2 went way down and to low at one point. For a thin guy I seem to make a lot of E2. Even before TRT my E2 was always high normal.
Just started .3mg a day of letro. I’ll report the results.
I always thought that letro was too powerful to be able to accurately dose for TRT. I would be interested in your results as I was on 1 mg/wk of Adex and E2 was still in the mid-50s. Doc increased me to 2 mg/wk and I am hoping for the best.
That is correct re letro. There have been reports that small amounts of letro took some to undetectable E2 levels. We do not know much else about this. We do know that anastrozole has a very linear dose response. I am suspicious that the reports of guys who had very low E2 from small doses of letro may simply be guys who would otherwise be anastrozole over-responders.
The big concern is the reported variability in reported responses. Also note that most such reports are in the context of body building steroid use and we thus have the issue of bro-data.
Would letro work well in a TRT context? We simply do not know. If some are having difficulties managing E2 with anastrozole it makes sense to see if letro has a better outcome for these individuals. Letro is a competitive drug and I cannot see why it should not be manageable. Read this if you do not understand “competitive”: Receptor antagonist - Wikipedia
I agree with KSman. The are several searchable studies that show letro, at 2.5mg a week, reduces high E2 while maintaining it in the physiological range. The effects of the drug have to be dose dependent. I feel I have no choice but to search for the correct dose since I still have E2 issues even on 2mg a day of Adex. Adex appears to have no further effect past 1mg a day. My labs showed almost identical E2 at 1mg a day and 2mg a day. My E2 was still high enough that when I would run HGH I would develop gyno. Interesting that I had zero gyno issues without HGH in the mix… Does HGH make cells more sensitive to other hormones? Would guys that don’t respond to TRT be responders with HGH added in? HGH is an interesting subject. Personally I love the stuff and I’m surprised it isn’t used more.
[quote]PureChance wrote:
If I had to guess I would say that it means there is something else wrong with your system that you are not addressing.
What else are you taking and what were your last blood test results?[/quote]
my arimidex dose was 2mg it is now 0mg
I lowered my T-Cyp from 200mg weekly to 100mg weekly
I eliminated my DHEA supplement
I increased my Vitamin D, ferritin, magnesium, and cortisol
I eliminated my Thyroid medication
Brent, how much hCG?
I’ve reduced my HCG to 200iu a week.
200iu a week seems very low. I am on 150iu EOD which is low compared to most.
if you have to take more than 100mg of T-Cyp a week then something else is probably off with your system.
What blood tests have you done (per the recommended blood test sticky)?
what other supplements/medication/vitamins are you taking?
Really need to go by TT and FT. Some guys need 300mg test ester to get to high normal range as they have an odd metabolism that clears T very fast. Otherwise, some need more because they are symptomatic on typical doses, as a result of receptor problems or some other aspect that comes alone with aging. But I guess this is really a long winded way of agreeing with your “then something else is probably off with your system”.
When higher doses are used to overcome an issue, this can mask other problems. In general, there can be bad aspects to things like that. However, there are things that can be not right that will never be understood.
I’m on 140mg a week of T. I feel that’s a reasonable dose and keeps my bioavailable T in range. Letro is just starting to kick in after 5 days. 6 drops a day and I can feel my mood improving. I have a feeling it’s going to take several weeks to straighten me out. My E2 has been high for a long time. No signs of E2 to low at this dose so far. From the research I read this dose “on paper” should be the sweet spot. I will run labs in a month.
Anyone try PT-141? Sounds like an interesting pep. I’ve lab ratted everything else so what the hell. I’ll take it for a test drive. I’m curious of the half life. I’ve read of effects lasting several hours to more than a day.
[quote]brentf13 wrote:
Anyone try PT-141? Sounds like an interesting pep. I’ve lab ratted everything else so what the hell. I’ll take it for a test drive. I’m curious of the half life. I’ve read of effects lasting several hours to more than a day. [/quote]
Wasn’t that the boat on McHale’s Navy? My memory isn’t what it used to be.
[quote]pcdude wrote:
[quote]brentf13 wrote:
Anyone try PT-141? Sounds like an interesting pep. I’ve lab ratted everything else so what the hell. I’ll take it for a test drive. I’m curious of the half life. I’ve read of effects lasting several hours to more than a day. [/quote]
Wasn’t that the boat on McHale’s Navy? My memory isn’t what it used to be.[/quote]
Yeah, man. I get it, Ernest Borganine, Tim Conway. I bet half the guys on this forum ,walking around with their underwear showing, have any idea what your talking about.
It can create abdominal distress that some might decribe as nausia for lack of a better reference. My reading indcates a 4-8 hour time delay for spontaneous libido, but might be working faster if one has a sexually stimuating event. The big problem is that we do not know what else it does. Dosing appears to be scrounging for data on WWW.
[quote]KSman wrote:
It can create abdominal distress that some might decribe as nausia for lack of a better reference. My reading indcates a 4-8 hour time delay for spontaneous libido, but might be working faster if one has a sexually stimuating event. The big problem is that we do not know what else it does. Dosing appears to be scrounging for data on WWW.[/quote]
Some people use a non drowsy form of antihistamine like claritin 30-45 minutes before taking the pt-141 shot and it supposedly prevents the GI distress in many cases. Apparently the reddening of the face still happens.
The reports of this working are just anecdotal, (more bro-talk) but this preventative technique to try and ward against several hours in the bathroom rather than ‘a great time’ is becoming more common in the BB community…so I’ve read.
Getting into uncharted territory…