You do not take a SERM to manage E2, anastrozole does that. SERM would be to create some LH/FSH to support the testes. hCG injections manages most of that realm. SERM’s have some side effects and taking SERMs for decades might not be a good thing.
As KSMAn said that you don’t take a Serm with TRT at all. Clomid and Nolvadex would be if you wanted to restart your system to produce testosterone on its own, or – you had a case of Gyno flare – in which case you should run Nolvadex – but never take it as part of a TRT protocol.