[quote]Bill Roberts wrote:
[quote]pradaboy wrote:
[quote]Bill Roberts wrote:
By the way, it turns out that hydroxytamoxifen is an antagonist at estrogen-related-receptor gamma, so if one wants to consume BPA-laden foods and probably be protected from that effect, Nolvadex likely will do it.[/quote]
That’s good info, so would a short cycle detoxify the body (to some degree?) or does it only offer protection from the moment you take it?[/quote]
It would only aid while actually in the system.
Actually as personal opinion I’ve thought for a while the possibility of low-dose ongoing tamoxifen usage (half or less the usual dose: in other words, 10 mg/day per less) is something that deserves serious consideration. I was really thinking from the standpoint of blood lipid profile and general health. Combatting xenoestrogens was an aspect I hadn’t considered.
Lower dose use has been looked at somewhat from the standpoint of breast health in women: http://jnci.oxfordjournals.org/cgi/content/full/95/11/766
As pure guesswork, I would be surprised if say 10 mg every other day was insufficient to completely counter any increase in ERR-gamma activity due to ingested BPA.
Really, the SERMs are quite cool. Estrogens do have some useful properties, but excesses of some activities are problems, and it is not an issue of every tissue and every receptor in the body acting the same way such that one is readily optimal in all regards. It works out very nicely that the SERMs generally provide estrogenic activity where that activity is good, and anti-estrogenic where there can readily tend to be too much activity.
(“Generally,” because for example men may find brain estrogenic activity of Clomid to be an undesired thing, or estrogenic activity of tamoxifen or clomiphene – though not raloxifene – in the uterus is non-optimal for women.)[/quote]
That’s a very interesting read, you might have good point there. Very interested to hear from you if you decide to try this.