His SHBG is high I believe, which means he needs way more testosterone to get optimal Free Testosterone. Yours is likely low (verify with a test), so you don’t need much testosterone to free up your FT. That’s how you can be low TT, while being high FT (the thing that matters).
The main problem I see is your E2 is too low. I would get more another male hormone panel again and check SHBG and thyroid panel.
Naza’s symptoms are not from testosterone, but from low estrogen. I have seen this before in people who starve themselves, they lose enzymes needed to convert to other hormones such as estrogen and even DHT.
These FT levels are optimal and where I would expect to see testosterone at this young age, but having low estrogen can cause debilitating fatigue, ED and low libido. TT is the junk hormone, it is bound to SHBG and isn’t bioavailable.
FT is the stuff that matters and you have plenty and the only way you could have this much FT with a TT <500 is having SHBG on the lower end.
Low estrogen is the cause of all your symptoms, sadly there is no easy fix. You’re just not converting enough FT->E2 anymore and probably lost the aromatase enzymes. We have another member struggling with the same situation who lost a lot of weight quickly through starvation who has chronically low estrogen.
I’ve had the H Pylori infection too. Its a bitch and tears your stomach apart. It took me months to figure out it wasnt an ulcer and was an infection. Took an antibiotic and it cleared it right up. Your stomach issues now probably have nothing to do with that. You might just be getting to the age where you have chronic gastric reflux that is completely unrelated to the HPI.
You dont need TRT with your free test so high. Dont even think about doing it. It has its benefits, but it can be a bitch to get dialed in. And if you ever want to discontinue it, i have heard it can be a bitch to get your normal production going again.
I started TRT because of anemia and I had low T symptoms. It helped tremendously but my case is different than yours. My estrogen was 48 pre-trt. My free T was likely on the low end due to higher SHBG. TRT lowered SHBG leading to more free T for me. You don’t have that issue.
Thank you for your responses, I appreciate it. I am not thinking about TRT at all at this point.
One thing I didn’t mention, At time of labs/currently I am on generic lamisil medication. Basically a medication that starves fungus on your body, I got bad toe nail fungus infections a few months ago, and I just finished the prescription, doubt it would effect hormonal panel at all but I’ll get some more labs in a few weeks to just be sure. Has potential to be hepatoxic but I didn’t notice anything in labs relating to elevated liver.
Now I am worried about about my estradiol levels, because it’s just about to be a over a year of being “cured” of h. pylori. Like you guys said, I was definitely “starving” for a few months last year, because even though I was eating little amounts of food, there’s no telling if it was even digested correctly as my stomach lining was completely ruined and I was on Proton pump inhibitors for like 4 months.
Btw, @backspinkc I 100% do not have gastric reflex. Before H. pylori infection I only had heartburn maybe twice in my ENTIRE life. gastritis affects people very differently, some unfortunate souls take YEARS, literally 3-5 years to recover from an h pylori infection/gastritis, it literally destroys your immune system + then the antibiotics wage nuclear war on your gut biome. You were one of the lucky ones who got cured with no complications lol.
it’s been a full year since I was “Starving”, I’ve been eating relatively good for 12 months now. I feel like my estrogen should have already recovered by now, but maybe it takes more time. Either way I’ll get a SHBG test and some thyroids done. any other recommendations would be appreciated.
Again thank you for your time, and I also feel bad for making all of you answer questions that have probably been answered a million times here. Is there somewhere where I can find basic ins and outs of interpreting hormone panels and their function etc?
I’m glad you decided against TRT. I started at 26 (you can read my log if you want), but just read through your post and don’t think that’s what you need right now. Your Free T is great.
However, that doesn’t mean you should entirely rule out working with an HOT doctor. They can work with you on other variables like thyroid. If the time comes that you DO need exogenous T, they can help with that too.
I’ll check it out! yes I will look into more detail. Obviously the longer I can just thrive naturally the better but I’ve always been about performance/mind/life optimization!
Which is why I’ve always been fascinated to jump on the AAS boat… but since my levels are ideal looks like at least a few more years of natty life
I read your entire thread. I was thinking what medications are you on the entire time.
I see you mentioned that anti fungal. Read the sides. What other meds are you on? Stopping med can be a life changer if possible.
Read what causes low shbg.
Your glucose is IMO high for fasting. It was in upper 90s. Insulin resistance may cause low shbg. I would test
A1c
Glucose again
Vit d
Vit B12 and folate
Magnesium RBC
Ferritin ( and if you can iron panel)
Prolactin
Fasting insulin
Am cortisol.
Need to take blood test within 1 hour of getting up
With ur gastro issues it’s possibly we are not absorbing nutrition.
Plus your cholesterol is on the low end and this is what makes hormones. Others mentioned this Your estradiol is low.
Keep us updated.
And yes I would not start trt. You still need to investigate.
And man you mentioned ED. You are young take Cialis or Viagra while you figure this out. . Very important to be able to F.
Edit. Not sure you mentioned ED. But just in case I gave you my thought.
I looked up the medication (generic Lamisil), and there doesn’t appear to be any hormonal side effects. Just potentially hepatotoxicity. Oh and depression . Which I in fact have been feeling the past 2 months. Luckily I have been off Lamisil for 4 days now, and won’t be taking it anymore hopefully.
I am on no medications, and I’ve never taken any medication chronically.
YESSS! I was worried about that too. My glucose was very high, pre-prediabetic. I don’t remember exactly, but most likely I ate a hugeee meal the night before the test on both tests. That’s my theory as to why my glucose is so high in both tests.
See the problem with my stomach is if I overeat beyond a certain threshold, or if I eat too large of a volume of food during a set time frame (let’s say like 3-4 hrs), I get severe heartburn. To mitigate this, I eat lots of small tiny meals constantly throughout the day… it’s the only way I can eat enough to support bodybuilding workouts and my active lifestyle… I am very slowly putting on muscle, but my weight has been the same for months now, rough average of 3100 calories a day.
For my next batch of tests, I’m going to have an actual “10 hr” fast and leave some comfortable space so I see if I need to worry about glucose. I sometime do intermittent fasting, but it’s hard with my gastro situation. I might start doing 48-72 hr fasts fairly more often as well.
A1c test would let me know if I need to take insulin sensitivity more serious.
Good recommendation but the erections are great on this end!
btw guys, I had this test done last week with Quest Diagnostics… so STILL while consuming Lamisil.
So these results are kind of confusing… are Estradiol levels susceptible to moving up and down so much?
Is that normal? it makes me think the Free Testosterone test I got done at LabCorp is bunk… because on that test it showed free Test of 25 pg/dL, and Estradiol of 13.6 pg/mL… Estradiol is inconsistent with these results shown below.
I’ll still go ahead and do all those other tests recommended to be sure.
So I know I mentioned no drugs or alcohol, but just to be transparent, I do consume mushrooms from time to time. And I use Kratom (5-8grams) every two weeks or so. I have deep tissue/myofascial release massages and I use it to numb pain. Just a thought.
Hey guys quick question here, I’m currently running labs on all the tests mentioned above. However, I got a Cortisol kit to and I have to collect saliva two times at same time each day.
Lab told me to do it at night, however I believe someone mentioned to do in AM, specifically remember @charlie12
I believe a key way to diagnose adrenal insufficiency is in the am. That’s when you cortisol suppose to be the highest.
So if it’s low in the AM … You have adrenal fatigue aka Addison’s or whatever they call it now
Suppose to take it very soon after you wake up.
When I went for the blood one… Lady told me I should get in by 730 or 8 am the lastest.
Some do a 4 point test. Am , afternoon, evening , midnight.
I think am most important one.
Also if evening or midnight cortisol still high… Explains why you can’t sleep. Then you making too much cortisol aka Cushing syndrome.
A diagnosis of primary adrenal insufficiency can only be made by an ACTH stimulation test. The low dose test appears to be more sensitive than the standard test.
Acute or chronic adrenal fatigue can be a serious disease. Its correct that this clinically relevant form is excluded by normal to high morning cortisol and normal ACTH levels.
However, there is much debate about a more subtile form of adrenal inusfficiency called adrenal fatigue. Proponents of this theory claim that morning cortisol and ACTH levels are not sensitive enough to detect this form of adrenal insufficiency (because it only becomes apparent after stress) whereas oponents claim that there is no such disease at all
Whatever, there is agreement that an adrenal stress test (ie the ACTH test) is the most sensitive and specific test to diagnose any form of adrenal insufficiency. As the standard, high dose ACTH test may trigger a large enough release of cortisol even in the setting of adrenal fatigue (false negative) the low dose test seems to be the best test if you want to get clarity about the ‘performance’ of your adrenal glands.