200mg Test Cyp/200mg Test E - AI Needed?

Pharma
21

I don’t necessarily believe in a “sweet spot”. There are so many multifactorial variables of which would dictate where you feel best at hormonally.

Some men feel great at 15pg/mL, others feel best at 40. No need to shoot for a specific number on paper (same for TT/FT), just find where you feel best.

2.5x the upper end of the ref range is excessive for HRT, same goes for TT/FT being 2.5X the upper end of the ref range.

Yes, the steroids subreddit appears to push traditional “party” drugs alongside absurd dosing of steroids. There are guys on there running a gram of trestolone per week. That’s insane given a replacement dose should theoretically be around 1mg/day (or slightly more).

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22

Look… AI’s aren’t good for you, but they’re probably not as poisonous as they’re made out to be. There might be some long term risk relating to neurological dysregulation and cardiovascular disease risk.

The studies dbossa/the vehemently anti AI crowd typically push pertain to rodent models or treatment for those with ER positive breast cancer being given 7mg anastrazole/week. It’s not particularly comparable to some guy using .25-5mg/wk.

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Thanks, I was actually gonna ask you about your opinion on long term AI use.

My understanding of the research is pretty much what you said. In post-menopausal women with breast cancer whose E2 has been crashed to almost undetectable levels, long term use is associated with neuro/cardio/osteo problems, so it’s a fair conclusion to reach that some E2 is cardio/neuro/osteo protective. I just never understood the leap from that to “E2 at 3x the range is totally fine, we don’t even test for it”.

Any difference between Anastrozole and Aromasin in your opinion? I know with Asin there’s no rebound because it’s a suicidal AI, and it’s apparently easier to dose/more forgiving (although harder to recover from an E2 crash since you have to create new aromatase enzymes), but I’m not sure about the safety profile.

When you say “AI’s aren’t good for you”, is there any evidence that they’re bad even if used only to keep E2 within the normal range, or do you think it’s just common sense based on your general understanding of human biology?

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My liver values and cholesterol improved when I dropped the ai. That is n equals 1 though.

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Do you know where you E2 was on the AI, relative to your TT/FT? Was it with the sensitive assay?

Any difference in mood with(out) AI?

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Exactly

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I took .125mg 2x per week, kept e2 at 45pg, lipids looked great (had started citrus bergamot at that time), BP was lower, felt great.

I’m trying a “only take as needed” approach now, and I just don’t feel as consistently good as I did on my old protocol. Prolly time to switch back

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Never understood that either. Like if a little of something is good, then a lot must be better.

Out of all their 216 studies, they have 1, from 2014, that showed men with e2 > 50pg had higher sex drive. And even that study is flawed. Everything else they’re comparing some e2 to no e2, and we all know that zero estrogen sucks

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It was with sensitive, e2 was like 18. I get fine there, and much higher, but we are all different.

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30

Thanks, that’s really good to know. I’ll know in 10 days or so where my E2 is after lowering my TRT dose. I’m hoping it’ll be within range but I’m not very optimistic given I was at 2.5x the range 6 weeks ago.

If lowering the dose doesn’t work, I’ll try the AI route. Have you ever taken or considered Aromasin?

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Interesting, that’s what my E2 was naturally before TRT. Wish I could keep it there now haha

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No, it being a suicidal inhibitor it deactivates the enzyme completely and your body must make more of them. That takes time. If you’ve crashed e2 then you’re now waiting longer to recover.

That’s my basic understanding, but i could be wrong

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That’s my understanding also, I just read it was more forgiving on dosing and because it’s suicidal there’s not “rebound” of E2 when you stop taking it.