2.5 Years of TRT Not Working that Well

Pharma TRT
41

TRH and increasing TSH can causes a rise in prolactin, people with primary hypothyroidism can see an increase in TRH which then increases prolactin.

42

I know. I just wanted to add another reason into his definitive list that couldnā€™t be added to by us forum docs.

43

Hypo = Slow

TSH up means slow, or under active.

44

my TSH was 1.8

45

What does that mean? LOL

46

I really hate how the replying to a particular post doesnā€™t show up correctly on this forum mostly the time. Makes it really tough to what you are responding to

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47

Im responding to @equel who somehow believes since his thyroid was not suppressed everything said is irrelevant lol

48

TSH is the least reliable biomarker, so when you say my TSH was 1.8, it doesnā€™t mean anything without thyroid hormone testing beside it. There was a member with full blown hypothyroidism at a TSH at 2.7, his fT3 was abnormally low 6 weeks after starting TRT, pre-TRT his TSH was <2.0.

Having a good TSH never guarantees you have optimal fT3/rT3 ratios, just like how there is secondary hypogonadism, if you had secondary hypothyroidism which is a pituitary failure and not a gland failure.

The communication between pituitary gland and thyroid must be optimal, I think a lot of men struggling on TRT have a little bit of both secondary hypogonadism and secondary hypothyroidism where they overlap unseen by laboratory testing.

A normal TSH is 1-1.5 in people who are healthy, these EDCā€™s are interfering with pituitary function increasing TSH to abnormal levels and is interfering with the HPTA function.

^^^^^

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49

what are u talking about?

50

@equel - Based on a trusted endo who used to post on this site, more testosterone doesnā€™t decrease SHBG.

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51

I mean mine went from 150 to 90 after I started TRT. Maybe just a coincidence? I donā€™t know.

52

My doc told me insulin sensitivity increases on TRT. Maybe there is an indirect relationship between SHBG and testosterone, but Iā€™m not sure itā€™s as black and white as saying more test = lower SHBG.

53

I doubt itā€™s that simple either.

54

When we start TRT it does lower shbg in men

55

You may inject too much testosterone, maybe you did not stay long enough on the dosage appropriate for you, and I suggest due to the high prolactin you have hypo function of the thyroid. Do you have thyroid labs?

56

More testosterone doesnā€™t decrease SHBG, testosterone cypionate does decrease SHBG on TRT in just about everyone because I have seen it occur day after day for the last 3 years.

How else can you explain a guy with high SHBG (68) all of a sudden 6 weeks later their SHBG is cut in half?

If TRT didnā€™t suppress SHBG, these men would never see FT increase at all and they would be screwed for life.

57

Thats so weird, as my shbg decreased from 24 to 13 a few weeks after testo gel, and now with 20mg prop, its 9!

58

If I am recalling properly he just got off an ai. He hasnā€™t even given it enough time. He raised his dose recently. Thatā€™s if heā€™s following the suggestions of someone he consulted. I asked the same person if heā€™d seen this post and he said ā€œyah I spoke to him
And he just changed his protocolā€ā€¦

I wish people could just be clear and straightforward when asking for help.

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59

Itā€™s called taking a left instead of going the right way. Takes a lot longer to get there if you take a left.

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