I’m extremely sensitive to hcg. 250 iusq even twice per week causes unpleasant water retention, puffy nipples, very similar to high e2 symptoms even when my e2 is low. It came down to 125 ius once per week. Ive also had a very hard time modulating my e2, even with microdosing adex. Low level depression and headaches seemes to come with the adex. I liked the idea of something with the potential to replace the AI and hcg. I’m always open to trying something new to better myself and how I feel.