SHBG is not been elevated by E2, lower T will increase SHBG a bit. Liver problems can increase SHBG. SHBG is made in the liver to scavenge sex hormones for return to and metabolization in the liver. Some simply have unexplainable high or low SHBG.
Your glucose and cholesterol labs were fasting?
Cholesterol should correct with low-T and thyroid issues resolved.
Your most obvious problem is thyroid and TSH should be close to 1.0, we are taking optimal and doctor are talking diseases.
fT3 is the only active thyroid hormone and should be tested directly. fT4 should also be tested directly. T3 uptake and free thyroxine indexes are indirect and not obsolete.
“my wife make all our meals using whole foods, etc.”
Not all whole foods are healthy.
With your thyroid numbers I think that you could easily be a T-gel non-absorbed and then injections are what you will need, 100% absorbed and also least cost.
Please read the stickies found here: About the T Replacement Category - #2 by KSman
- advice for new guys - need more info about you
- things that damage your hormones
- protocol for injections
- finding a TRT doc
Evaluate your overall thyroid function by checking oral body temperatures as per the thyroid basics sticky. Thyroid hormone fT3 is what gets the job done and it regulates mitochondrial activity, the source of ATP which is the universal currency of cellular energy. This is part of the body’s temperature control loop. This can get messed up if you are iodine deficient. In many countries, you need to be using iodized salt. Other countries add iodine to dairy or bread.
KSman is simply a regular member on this site. Nothing more other than highly active.
I can be a bit abrupt in my replies and recommendations. I have a lot of ground to cover as this forum has become much more active in the last two years. I can’t follow threads that go deep over time. You need to respond to all of my points and requests as soon as possible before you fall off of my radar. The worse problems are guys who ignore issues re Thyroid, body temperatures, history of iodized salt. Please do not piss people off saying that lab results are normal, we need lab numbers and ranges.
The value that you get out of this process and forum depends on your effort and performance. The bulk of your learning is reading/studying the suggested stickies.
Your thyroid issues may be from an iodine deficiency and your wife may be using sea salt. She would be deficient too and she needs temperatures checked as well. Yes sea salt and pink salts are natural, but thyroid problems are a natural state as well when not using iodized salt and iodine from supplements.
Does your multi-vit contain 150mcg iodine and 150-200mcg selenium?
Total T4=6.3 should be near mid-range and your result suggests iodine deficiency.
Is stress a major factor in your life? Any major stress events? accidents, surgeries, illnesses etc?
GH and DHEA status looks great.