Topic Organisation

[readalot]

…there’s that pesky term optimal again.

@galgenstrick

When staring a protocol it is important to find a doctor that will prescribe a full replacement dose. This is typically above 120mg per week up to 200mg per week. If prescribed less than the replacement dose, there is a good chance natural production will shut down and the exogenous testosterone will not be enough to bring testosterone levels to an optimal level. In that case, you will be worse off than when you started

@readalot

In conclusion, these were results tailored to my volume of distribution and clearance rate. Those two parameters for you will be different. See this paper. Therefore, if you want to run physiologic ranges (which by definition is TRT), you’ll need to map your peak and trough to your dosage and dosing frequency. See for example the exchange here I had with our good friend Danny. He and I have very different clearance. You can see from the plots above that having a trough at 1000 ng/dL when dosing either weekly or biweekly with TC is not TRT and depending on your dosing frequency you may be spending a majority of the time above physiologic range. In my particular case this caused elevation of Hct, higher BP. Upon switching to 70 mg/week of TC and staying in range all of the time, all these issues went away.

So when you read on here that 75-100 mg per week of TC is not enough for TRT, you need to do the work and determine if that is true for you. Just throwing out dosages is meaningless until you experimentally determine your clearance. Good luck and best wishes with your TRT.

For a good example of starting off on a TRT protocol, see this thread . Warms my heart that some people are getting pointed in the right direction when starting TRT.

Optimize what?

The claim that many/most will need more than 100 mg/week of Test ester for replacement continues to baffle me.

Running “TOT”? Great. Just don’t kid yourself or mislead others trying to learn.