T Increasing, E2 Decreasing on TRT, No AI. Why?

Sust has less T than T cypionate or enanthate, so 120mg/week in two divided doses would be good. You can also then use those other forms of T at 100mg/week.

What is your long term history of using iodized salt?
Are you a vegetarian? If so, probably B12 and folate deficient and possible essential amino acid deficiencies.

Are you near any of the alluvial deposits from the mountains that cause high cyanide levels in well water?

You may have more than single causes.

Magnesium deficiency causes muscle cramps, more often foot or legs.

T4 will not work if T4–>T3 conversion is poor or impaired. Low ferritin could do that, typically an iron issue which would be unusual for a male unless there is a GI bleed or blood loss. If reverse T3. rT3 is elevated, it blocks some of the actions of fT3 which is the active hormone. Please see last paragraph in this post.

Adrenal fatigue can lower cortisol, hydrocortisone is dangerous if used long term, can be very catabolic and body shape can change, tendons have been known to break, T levels drop. This suggests adrenals, maybe adrenal fatigue.

You have primary hypogonadism. Have your testes been checked by a doctor? Any aches?

Please see all of the following and then come back with some questions based on what you have read.

Please read the stickies found here: About the T Replacement Category - #2 by KSman

  • advice for new guys - need more info about you
  • things that damage your hormones
  • protocol for injections
  • Thyroid Basics
  • finding a TRT doc

Evaluate your overall thyroid function by checking oral body temperatures as per the thyroid basics sticky. Thyroid hormone fT3 is what gets the job done and it regulates mitochondrial activity, the source of ATP which is the universal currency of cellular energy. This is part of the body’s temperature control loop. This can get messed up if you are iodine deficient. In many countries, you need to be using iodized salt. Other countries add iodine to dairy or bread.