SQ/SC is slower smoother release, less peaks and no decades of muscle damage. Easiest to visualize top of upper leg. Pinch up skin and inject into end of fold with needle parallel to muscles below.
So get lumps in belly fat and not in upper legs, some vice verse, so see what works best for you. Many do SC/SQ with no discomfort. I often feel nothing.
SHBG is increased with more E2 and decreased with higher T levels. SHBG does not typically become a problem with TRT if TRT is managed properly. TRT probably decreases SHBG. Some for reasons unknown simply have low SHGB. Diabetes can cause low SHBG. Starvation diets and liver conditions/disease can lead to high SHBG.
With TRT, if E2 is well managed, near 22pg/ml - 80 pmol/L for most, and FT is good, there is no compelling reason to test SHBG. If TT high and FT disappointing, SHBG suspected elevated. If FT is oddly high, low SHBG is suspected. There is nothing that can be done to directly change SHBG, so other best practices are all that can be done. AST/ALT should be part of labs to see if liver is OK. T does not cause liver problems, some think that is possible, but that is from body builders using high doses of other anabolic substances, orals are the major problem.
Pea Nut Kid is sowing bad information and dumb dosing ideas. Then I need to write this to undo damage.
Please read the stickies found here: About the T Replacement Category - #2 by KSman
- advice for new guys - need more info about you
- things that damage your hormones
- protocol for injections
- finding a TRT doc
Evaluate your overall thyroid function by checking oral body temperatures as per the thyroid basics sticky. Thyroid hormone fT3 is what gets the job done and it regulates mitochondrial activity, the source of ATP which is the universal currency of cellular energy. This is part of the body’s temperature control loop. This can get messed up if you are iodine deficient. In many countries, you need to be using iodized salt. Other countries add iodine to dairy or bread.