Past studies have shown that elevated estradiol levels could inhibit penile erection, but the relationship between estradiol and erection of the penile tip or base has not been extensively researched.
Methods
We therefore investigated estradiol’s effects on the erection of the penile tip and base, with a cross-sectional study of 135 patients with erectile dysfunction (ED), based on scores of ≤21 according to the International Index of Erectile Function-5. All patients were tested for nocturnal penile tumescence, blood pressure (BP), serum glucose, total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin (PRL), progesterone (P), estradiol (E), and testosterone (T). Univariate and multivariate analyses were used to assess associations between estradiol levels and erection at the penile tip and base.
Results
We found no obvious relationship between erection time at penile tip and estradiol levels but did observe a negative correlation between base erection time and estradiol level [hazard ratio (HR): ‒0.11; 95% CI: ‒0.80–1.72]. With increasing estradiol concentration, multivariate analysis showed an obvious reduction in base erection time among patients with normal Rigiscan results (HR: ‒0.31; 95% CI: ‒1.63–1.29) (P<0.05) as estradiol concentration increased.
Conclusions
Our data indicate that estradiol inhibits penile erection, particularly at the penile base. Also, when the effective erection time of the penile base lasts longer than 10 min, estradiol has a more obvious inhibitory effect on penile base erection.
Crazy how we get a recent study showing e2 is needed in the brain to stimulate libido, but also have studies showing too much will hurt your erection. Pretty clear that there is a “optimal zone” for every guy to function their best.
I also think that the increase in Cialis use allows a lot of guys to have higher e2 levels yet still experience an erection, maybe masking the effects somewhat?
It would be interesting if research existed investigating a transient bio mechanical relationship between e2 and dorsal vein stiffness. This might provide a tissue stiffness range for optimal in/outflow rates for filling and drainage during erection as a function of serum e2 level.
Theres a sweet-spot, yes. ANY GEAR HEAD who have been doing tons of test shooting his e2 into outer-space will know this shit, its 100% obvious. U cant just fucking increase e2 to the moon expecting it to be all great.
These idiots in the … well, you know which group, keep spouting about how great high e2 is … then u find out all of them is using fucking cialis and 50% of those folks have god damn gyno, lmfao
While blasting, I think erections have been really good this time around. I am dosing adex at .25 mg EOD. Also using Cialis at 12.5 mg EOD, but was doing that in cruise too.
On TRT the last 2 years and my e2 was always top of the range and sometimes slightly above (55 pg/ml). Erections felt ok, but now that I started running an AI .5mg arimidex Monday and Thursday, I notice that my erections are way harder, I get there much faster. Also morning wood returned regularly and I find myself randomly hard throughout the day. I have no idea where my e2 currently is, I’m getting it measured in the next couple weeks, but it’s interesting how e2 is related to this. I never agreed with the whole let your e2 run out of control. Everyone is affected differently. I got on arimidex to try to stop breakouts and so far it seems to be helping. While other guys with high e2 have no issues. There is definitely a sweet spot for some of us. From what I’m seeing 20-30 pg/ml seems to work for many. Anything higher or lower and they run into issues.
Not surprised by this. When my E2 is high my junk turtles up. Embarrassed to even let a girl see my flaccid “hang”. Pretty much the opposite feeling of an Alpha Male.
Bros have Been noticing things like this for decades, hence why trt doc started to look into it.
Then came the anti-ai crowd along and now we have tons of ppl on trt WHO cant get their cock Hard. The advice? “Up THE dose man, i think u need higher e2”
Seriously? We have a ton of people who cant get their cocks hard? The fear mongering is on ultra high these days. No, there isn’t a ton of people with this issue.
He’s implying that TRT, and high E is causing ED. No its not. Many come here with those already existing issues hoping TRT is the answer. So how can it be the TRT is what is causing this?
It clearly is, and its rampant over the boards. This high e2 nonsense is just that, complete and utter nonsense. (Too) high e2 is not good for you, have never been and never will be - if u dont want to be a female, that is.