Improved sexual health, a healthier prostate, and powerful pee streams? Here's what you can expect in the first few days, the first two months, and beyond.
How do you know when a supplement or an ingredient is working? Sometimes, it's easy. Take a scoop or two of a good preworkout and you'll feel it... fast. Other supplements are trickier. For example, some ingredients can help you avoid certain disease states, but you don't really feel much.
That's why we put together this series. Here, we'll tell you what you can expect in the short, medium, and long-term from different ingredients. Previously, we covered:
- The nutrient partitioning agent, cyanidin-3-glucoside.
- The Malaysian testosterone booster and aphrodisiac, LJ100.
- The body composition agent, forskolin carbonate.
Now, let's look at a multi-ingredient formula designed primarily for prostate support, vascular sexual health, and urinary tract health – Biotest P-Well (on Amazon). This formula contains punicalagins (180 mg), lycopene (30 mg), and cranberry extract (500 mg).
✅ Short-term expectations: First 3 to 14 days
Users notice effects related to urinary comfort and vascular tone first:
Urinary health and flow: Reduced urinary urgency and fewer nighttime bathroom trips. Cranberry polyphenols improve the urinary tract lining and blunt irritation that makes men feel like they need to pee constantly. Users also notice a stronger urine stream and have an easier time starting due to the anti-inflammatory effects of punicalagins and cranberry compounds, which help reduce swelling in the urinary tract.
Circulation and vascular feel: Men report a light improvement in pelvic/perineal circulation. Punicalagins and lycopene both increase nitric oxide bioavailability and improve endothelial function. These changes often show up early as a "warmth" or better pelvic blood flow.
General well-being: Better urinary comfort and less nighttime waking translate to better sleep and improvements in daytime mood and energy. Early reductions in oxidative stress markers have been shown with punicalagins, which lower systemic inflammatory load and can make people feel subtly "clearer."
✅ Medium-term expectations: 4 to 8 weeks
This is where the deeper prostate and hormonal-environment benefits begin to become noticeable:
Prostate function support: Users begin to notice a healthier prostate size and function. Lycopene reduces oxidative damage to prostate tissue, thereby helping to preserve normal cell signaling and mitigate hyperplasia-associated swelling. Pomegranate compounds help reduce inflammation and support healthy hormone metabolism within prostate tissue.
Users also notice more complete bladder emptying. As inflammation decreases and the prostate becomes less reactive, men experience stronger flow and less residual urine, which improves comfort and reduces the feeling of always needing to go again.
Both lycopene and punicalagins also support healthy PSA dynamics by protecting prostate cells and reducing the inflammatory drivers that can elevate PSA in older men.
Urinary tract resilience: Cranberry proanthocyanidins make bacterial adhesion to the urinary tract lining far more difficult. This translates to fewer flare-ups, less irritation, and better long-term urinary comfort.
Vascular sexual health: Improved endothelial function tends to show up more clearly by this stage. Users notice better erection quality, especially firmness and fullness, due to improved blood flow and nitric oxide function. Lycopene also improves sperm health, mainly through reducing oxidative DNA damage in cells.
✅ Long-term expectations: 8 weeks and beyond
This is where tissue-level protection, antioxidant power, and long-term prostate aging benefits accumulate:
Prostate longevity and cellular protection: Punicalagins and lycopene reduce oxidation, DNA damage, and chronic inflammation inside prostate tissue, which is strongly associated with maintaining long-term prostate health. Long-term lycopene intake is strongly correlated with lower rates of prostate enlargement progression.
Stabilized urinary flow and nighttime relief: Users often describe this as a return to "young guy peeing," meaning fast flow, reliable emptying, long stretches without urgency, and minimal nighttime waking.
Cardiovascular and circulatory benefits: Punicalagins improve blood flow, reduce LDL oxidation, and improve endothelial function. Over time, this supports better erection quality, better exercise pumps, and improved overall vascular health.
Systemic antioxidant and anti-inflammatory benefits: Punicalagins are among the strongest dietary antioxidants available (3x stronger than green tea or red wine). Long-term intake supports lower chronic inflammation, healthier blood vessels, better nitric oxide signaling, and reduced oxidative load on the brain.
The bottom line
Here's what users can realistically expect from P-Well (on Amazon):
Short-Term
- Better urinary comfort
- Fewer nighttime bathroom interruptions
- Stronger flow / easier starting
- Early circulation improvements
- Better overall sleep and comfort
Medium-Term
- Noticeable bladder emptying improvements
- Reduced urgency and frequency
- Better prostate function and PSA stability
- Improved sexual blood flow and erection quality
- Stronger urinary tract resilience
Long-Term
- Long-term prostate protection
- Consistently strong urinary performance
- Better endothelial and circulatory health
- Enhanced antioxidant defense
- Subtle cognitive and mood benefits through improved sleep and reduced inflammation
