Age=52
2.5mg anastrozole per week is insane, as well as resultant E2=20pg/ml
please provide the T3 lab range, it its midrange is 3.2, then something is wrong
Please post oral body temperatures as suggested in this sticky: Thyroid Basics Explained
And see others here: About the T Replacement Category - #2 by KSman
hematocrit [HTC] 43.1 is very wrong for your T levels, suggesting a GI bleed blood loss.
any digestive issues or food allergies/sensitivities?
get an occult blood test done to detect blood in your poop
HCG 1200mg/week could be driving a lot of T–E2 inside your testes and [a competitive AI] anastrozole cannot control that and maybe that is the problem. A few guys are quite prone to this issue.
Prostate inflammation was sudden onset? suspect infection, it does happen. An antibiotic would then be needed. Otherwise, many guys on TRT do not have any problems with there prostate over years of TRT. In my case, my PSA slowly gets lower over the years.
diet: You may be having protein hungers and other food does not help. Try some protein shakes and see if that helps. The hCG can be a factor in you body utilizing more amino acids. But TRT alone can do this.
I think that you should go to 100iu hCG EOD and see if E2 drops. If that is happening, you may need to take anastrozole down near 1mg/week. If E2 crashes, you might feel bad quickly.
That anastrozole is probably stopping T–>E2 in peripheral tissues where this can take place for local utilization. While such effects are really not understood, some are aware of the potential for problems.