Honestly, you have to be careful with that stuff. My pregnenolone was always low so I supplemented with it and felt MISERABLE!!! I don’t know how to describe it but felt like I was crawling out of my skin. I have low end t3 and t4 and had a bit of brain fog and fatigue issues. It actually turned out to be from diet and too much caffeine. Even though I “ate healthy” dairy and gluten was irritating me mentally. Supplementing with just 50mg of pregnenolone ended up converting to progesterone and sent mine 3x higher than it should be within a week. Be careful.