On TRT 5 Years, Now Feeling Mental Sides. Input on Bloodwork?

Recent Labs Fsh <0.30 mlU/ml Males 1.4 -18.1 mlU/ml
Prolactin 8.00 ng/ml Males 2.1 - 17.7 ng/ml
DHEA, Non Sulfate 2.5 ng/ml standard 1.5 -9.2 ng/ml
LH <0.07 mlU/ml Males 1.5 - 9.3 miU/ml
Vitamin B12 406.00 pg/ml standard 211.00-911.00 pg/ml
Folic Acid 12.04 ng/ml >5.0ng/ml
Vitamin D 27.60 ng/ml 30.00-100.00 ng/ml

My numbers are all over the place. Im having severe anxiety and depression and not improving. Do these numbers have anything to do with it?

TESTOSTERONE 727.75 ng/dL 123.06 - 813.86 ng/dL
TESTOSTERONE FREE, CALC 237.8 pg/mL 30.6 - 152.0 pg/mL H
TESTOSTERONE FREE PCT 3.3 % 1.0 - 2.8 % H
TESTOSTERONE BIOAVAILABLE 557.5 ng/dL 72.0 - 355.0 ng/dL H
TESTOSTERONE, BIOAVAILABLE % 76.6 % 23.6 - 65.8 % H
SEX HORMONE BINDING GLOBULIN 13.10 nmol/L 14.55 - 94.64 nmol/L

Your labs explain everything, your levels are way too high, you’re low SHBG and should be injecting smaller dosages (8-10mg) every day. You need to target 500 ng/dL are you will always have trouble with estrogen.

More frequent smaller injection should lower the estrogen peaks. I had problems in the 600’s and my SHBG is higher than yours. When are you drawing labs?

ESTRADIOL 41.5 PG/ML <=60.7 PG/ML

37.9 (imarch)
18.9 (may)
41.5 (june)

I havent had any problems for 5 years. The past year I had the increase of estrogen next month too low now too high again.

This is what happens when a low SHBG guy injects large infrequent dosages, levels swing wildly. Your body changes after a while, what you need 5 years ago isn’t what you’ll need years from now.

Describe your protocol in detail.

Has diet changed?

Were you physically active before compared to now?

No . same as always .

i tried the 1 mg a week cause i did really well on .75 a week for 5 years, Dr recently raised me to 1mg a week, ive tried .5 on wed and .5 on sunday, i stopped taking the Al when i dropped to 18, diet has always been the same, activity i play golf once a week and softball once a week then tournaments on saturday, even though for the past 4 months nothing has excited me

Does LH have anything to do with anything? .07 sounds like an issue when males should be between 1.5 - 9.3

You need to describe in mgs, not decimals. You’re going from .75 to 1 mg and is confusing. You never have stated the AI dosage.

It’s obvious you need better care. It sounds like your estrogen is not being properly managed, all you needed was to lower your AI dosage.

i was actually never told exactly how to manage, i have only done what ive read, im sorry when i used decimals it was CC, i was on 150mg a week and then Dr up’d that to 200mg a week, i tried 100mg on wed and 100mg on sunday, but for 5 years i did 150mg once a week on friday and never had any issues, as far as the Al im not really sure how to take it, i cut it into quarters and tried that but i think i crashed my estrogen before that by taking a full pill 1st time then half a pill twice a week for a few weeks

So if you were me, how would you handle this as far as injections and Al? i’m willing to try and stick to anything to get me back to where i was, thank you systemlord

I am you, my SHBG is low (16-18) and this dictates that I inject 15-20mg EOD, those larger dosages are probably hammering your SHBG levels a little bit. I joined with an anti-aging clinics so I could have access to custom compounded doses of arimidex, this is a must since you are clearly an AI over-responder. If a .25 AI is too much what else you going to do?

You may be able to get away with an EOD protocol, you may also need to go on an everyday injection protocol if you can’t get that SHBG higher. I’m thinking high doses are lowering your SHBG since it’s the larger doses that are used with guys who have very high SHBG, to a low SHBG guy I expect a similar protocol to be disastrous.

Low thyroid function can also explain low SHBG, low Free T3 and a combination of high Reverse T3 is bad and spells low SHBG. Low thyroid function slows down every cell in the body, including the liver where SHBG is made.

I realize thyroid labs were down, but thyroid problems can be intermittent. Check thyroid per thyroid sticky, you can check thyroid status by checking morning and afternoon oral body temperatures.

i had my thyroid checked and all those numbers were good. What anti aging clinic? You talking about one like Defy Medical?

Defy medical, just joined myself. These guys do all the work for you, you don’t have to figure everything out anymore. I’ve seen guys run thyroid labs one months and doctors orders another one a month later suspecting an issue and tests catch the thyroid redhanding acting up.

Defy medical prefers to start out an AI on the low side if one is warranted. 1mg can be too much for some and an over-responder usually needs a very, very tiny amount.