On TRT 5 Years, Now Feeling Mental Sides. Input on Bloodwork?

.75 ml/week of 200mg/ml T = 150mg/week T ?

When you inject once a week you get a high T peak then a trough level. Then your lab results are largely determined by lab timing and thus relatively useless as a measure of your hormone status.

E2 is killing you.

  • Inject 75mg twice a week
  • Get Rx for 0.5mg anastrozole oral at time if each T injection.
  • Always do labs halfway between injections to eliminate lab timing changes to lab results.

Target is E2=22pg/ml which seems optimal for most guys for:

  • fat levels
  • fat patterns
  • libido
  • mood and tolerance
  • energy and initiative

We normally ask that guys inject 250iu hCG subq EOD to preserve testes and fertility. But after 5 years there may be no point with permanent damage.

We find that even with optimal T and E2 levels guys with low thyroid function have most of the same symptoms as low T. See below and post oral body temperatures and discuss your history of using iodized salt or vitamins that list iodine, selenium.


Please read the stickies found here: About the T Replacement Category - #2 by KSman

  • advice for new guys - need more info about you
  • things that damage your hormones
  • protocol for injections
  • finding a TRT doc

Evaluate your overall thyroid function by checking oral body temperatures as per the thyroid basics sticky. Thyroid hormone fT3 is what gets the job done and it regulates mitochondrial activity, the source of ATP which is the universal currency of cellular energy. This is part of the body’s temperature control loop. This can get messed up if you are iodine deficient. In many countries, you need to be using iodized salt. Other countries add iodine to dairy or bread.

KSman is simply a regular member on this site. Nothing more other than highly active.

I can be a bit abrupt in my replies and recommendations. I have a lot of ground to cover as this forum has become much more active in the last two years. I can’t follow threads that go deep over time. You need to respond to all of my points and requests as soon as possible before you fall off of my radar. The worse problems are guys who ignore issues re thyroid, body temperatures, history of iodized salt. Please do not piss people off saying that lab results are normal, we need lab number and ranges.

The value that you get out of this process and forum depends on your effort and performance. The bulk of your learning is reading/studying the suggested stickies.