No Sex Drive, Low Test and High Estrodiol. HELP!

@KSman I’m looking for some advice please

I tried a restart with HCG, 250iu EOD but after about a week / 10 days I felt like it was shutting me down, so I went with more of a power PCT (which I know you don’t approve of) 1000iu EOD for 2 weeks and went to get bloods done after my last HCG jab.

These were my results, which I’m very pleased with as my T has increased from 15 to 25…

Test Time: early morning
TESTOSTERONEPlasma testosterone level (XaltQ) - 25.5 nmol/L [6.0-27.0]

LH/FSHPlasma
LH level (XaElA) – 5.6 u/l [0.7-11]Plasma
FSH level (XaELZ) – 3.3 u/l [.08-7.7]

SERUM SEX HORMONE BINDING GLOBULIN LEVEL (44CD.)
Serum sex hormone binding globulin level (44cd.) - 20 nmol/L [13.0-71.0]

17 B ESTRADIOL
Plasma oestradiol level (XaEQo) - 170 pmol/L [male up to 73]

PROLACTIN
Plasma prolactin level (XaELY) - 225 mu/L [0.0-280.0]

Those results were from 10 days ago, since then I have been taking aromasin 25mg ED and Tamoxifen 20mg ED

I was wondering what my next step would be to stop taking these in which order and if I should taper off??

Please clarify. You were ONLY taking 1000iu hCG EOD, no other medications?

Your LH/FSH should have been shut down. Were you also taking a SERM?

Your testes were exposed to the hCG and LH=5.6 and LH receptors would be overstimulated and high testicular T–>E2 is expected; and anastrozole cannot control that. So taking anastrozole will only reduce T–>E2 aromatization in peripheral tissues.

Do you feel better with aromasin 25mg ED and Tamoxifen 20mg ED since 10 days ago?
Aromasin is not a competitive AI and how it works VS intratesticular T–>E2 is unknown. When you take Tamoxifen, LH will be higher again and more T–>E2 inside the testes may lead to higher serum E2 even with the AI. It seems counter intuitive and is something that few doctors will ever understand.

High E2 can kill libido, lower energy and make guys bitchy and intolerant. Can block many of the benefits of good T levels.

@KSman was taking letro with it to try and control my e2. I started tamoxifen @ 20mg the day before my last HCG jab, and went for the test the day after the last HCG jab. So I would have taken tamoxifen for 2 days before my test. Would that of had an effect on my natural LH levels that quickly?

I wouldn’t say I feel much better no. I did have one day where it felt like my sex drive was well on its way back which was about 7 days after I finished the HCG, but that only lasted 1 day. I’m wondering if I naturally have a higher e2 level and that it’s too low(due to aromasin) even though it’s never been in range. I have no idea what it’s like to have low e2, I’ve tried my best to crash it and I’ve not been able to, if I take a high dose of an AI I struggle to sleep so assumed that’s my e2 lowering but it’s never tested low.

The SERM explains the labs. But with this transition, its hard to attribute results. Your testes are working well. Your hCG dose did not see sustainable. So its hard to say what dose of what would be appropriate. You need to try something more reasonable and be on that steady for a while so we know what the labs related too.

My plan was to stay on the tamoxifen for a few weeks and get re-tested, then come off of everything and get another test 6 weeks after that. What are your thoughts?

I put a lot of effort into the HPTA restart thread. I addressed tapering off and cruising on anastrozole. Have you read that?