My journey with TRT

My new labs results are in; done after 2.5 months on TRT.

PSA 0.6
T3 free 3.4
T4 free 0.89
THS 1.65
E2 30.7
TT 744
FT 19.4
SHBG 38.9

The decrease in E2, TT and FT may be a result of a lower dose (140mg to 120mg), adaptation or that I did subq injections for a couple of weeks (went back to IM a week before the test.) This was all without AI.

My libido is still very low. In the last week (after the blood draw) I took some Arimidex (about 0.6 mg) and seems it lowered my libido even more.

Do you know if that was the Ultrasensetive test for e2? Should post ranges always.

30.7 is not bad though, even if it is the wrong test (are you having symptoims besides the low libido?). I think there is some validity to the incorrect estradiol test, if you are too high or too low.

How was your libido when you were NOT messing with the AI at all? Low libido could be caused by a couple things, not just E2.

With your SHBG in the higher range, are you still doing 3 injections a week? (more frequent injections are better for low shbg)

You got it all wrong, you are on a protocol designed for someone who has low SHBG who can’t hold onto their T well enough and now you wonder why you are seeing hardly any benefits?

There’s no reason for you to inject multiple time a week, you need those large peaks to get SHBG to midrange in order to increase FT.

I went back to 2 IM injections per week, one week before the test.
E2 was ultrasensitive in the prescription and the normal range is 8-35.

I talked to my endo today. We agreed to reduce the dose to 100mg a week and not use arimidex.

Good idea. Don’t immediately take a dose of AI if you start feeling slight e2 symptoms, give them a day or so, sometimes they pass.

HCG dose was also increased to 2x550 IU per week because my testicles have been shrinking. I have a wild guess as why: maybe my belly fat (which is quite a lot) absorbs some of the medicine?

I realized I had added twice the amount of needed water to HCG. I’ll be injecting 800 IUs each time now.

Related to low libido and ED, my doctor added DHT to my next blood test but I doubt I have low DHT as I have acne and increasing facial hair. Mystery!

Everyone’s different, some people just have lower levels of everything and do just fine. I have no idea what mine are only that I’m extremely horny all the time and I not even 100 percent yet, it would be interesting to see where my DHT level.

Acne is driven by E2 levels.

One thing I’ve noticed in the past couple of months is that my skin has become very dry. I’ve always had very oily skin so I’m surprised. It’s so dry it hurts when I shave. It’s mentioned here that low E can cause dry skin but I doubt I have low E.

Absolutely, I even had dry eyes when my E2 was low. High E2 always makes my skin moist, I can remember a time when it hurt to shave. It could just be transitional, first few month for me was a bit inconsistent.

Interesting. I read somewhere that if your E is low then Viagra won’t help with your erections and this is what happened to me a few days ago. Although the Viagra I have is from my antiaging clinic and and the label says “sildenafil 36mg”.

Subq injections work well, 100% absorbed, over upper leg.

You seem to have ignored the section I posted about oral body temperatures and thyroid function. TSH should be nearer to 1.0 suggesting that you may be iodine deficient from not using iodized salt.

hCG can be tested with a home pregnancy test. Everyone injects hCG subq, your belly fat is not different.

E2 too high, go for E2=22pg/ml
Increase dose by a factor of E2=30.7/E2=22

fT3 should support good oral body temps. fT3=3.4 suggests maybe some rT3 resistance.

We still need lab ranges.

Please may this the only thread that you maintain for your case.

Can you get your T dose increased by 30%? That would also require a similar/further increase in anastrozole. You can stack both dose corrections.



No Iodized salt. I have a kelp supplement but forget to take it regularly. How can increasing the dose decrease E2?

Am I the only one injecting testosterone subq in belly fat? Where do you inject on upper leg maybe I could try that . Is there a youtube video that shows the exact location on upper leg?

I do subq belly.

Some get sore lumps from injecting into belly fat, some sore for legs. Find what works for you.

Anywhere subq upper leg, look for and avoid surface veins if visible. Skin on upper legs can be sort of insensitive which is great. If you hit a vein, it has nerves, but the location of the pain is diffuse, you can back out, and try a different location, you can recap needle, swab a new area, re-swab the needle and go again. About aspirating: if you go through a vein and out the other side you will not see blood. [So I do not bother.] After injection, pull needle and immediately press firmly on puncture site for 10 seconds to allow tiny vessels to seal of and prevent bleed bruises. As you inject into pinched up mount of skin you can feel the swelling of the injection, it not could be into a vein.

What is your opinion on doing subq in the fat pads of the buttocks?

Labs are in many ways very impressive. But I think that your total cholesterol is too low as cholesterol is essential for many bio-processes.

fT4 is well below midrange suggesting iodine deficiency.
Still need to see oral body temperatures and info re your iodine intake.

How are they impressive?
I eat quite a lot of olive oil, eggs, pumpkin and sunflower seeds so I don’t know why my cholesterol may be low. I know that psyllium husks (that I add to my whey shakes) lower cholesterol.

I can’t find the thyroid sticky.