Klippe: An HRT journey

Hi All, back again after the latest labs…the labs were done two days after last doses, which in turn is the day of my next doses (EOD)

The results are as follows:

E2: 134 pmol/L (Range 40 - 161)
TT: 24 nmol/L(Range >12 nmol/L)
SHBG: 19.2 nmol/L (Range 11.1 - 78.1)
FT: 691 pmol/L (Range 180 - 739)

I am happy with the TT levels and fairly happy with the FT levels. My E2 levels are about 40 - 50 points to high. My SHBG has also increased a bit. So I suppose I should increase my AI (anastrozole) dosage? This will bring down both the E2 count and SHBG, not so?

My question now is by how much would I increase my AI dose?

To help answer the above, the following is my current dosing:

Test Cyp: 0.25ml of Test Cyp (250mg/ml) 3 x week / EOD (Total 0.75 ml = 187.5. mg Test Cyp / week)
HcG: 250IU 3 x week / EOD = 750 Iu’s / week
Anastrozole: 0.32 mg’s 3 x week / EOD = 0.96 mg’s / week

Is the E2 level and Anastrozole dose linear?

Would that mean that I would have to calculate the increase in my AI dose by:
80 (desired E2 level) / 134 (current E2 level) = 0.6
Current dose giving 0.6 = 0.96 mg’s / week. Therefore new dose would be 0.96*/0.6=1.6 mg’s / week = .53 mg’s 3 x week / EOD.

Is that right? It seems a bit excessive, especially considering that in the posts above I thought I was an AI over responder…

I am at a loss for words seeing as my new labs show the same level as the previous labs and this after the Test does was reduced by 75%. It seems that this reduction in Test had no effect on the E2 level at all. Is that even possible?

I am even wondering whether my body may be taking a very long time to respond to the therapies, although the T levels did decrease with the exact factor of the decrease in dosage so E2 is the problem…HEEELLLPPPP :grin:

Thanks, all help would be greatly appreciated…

Cheers

Klippe