Is TRT Safe? Here's What a Big New Study Says

I hope things get better for you and your country’s economy, my friend.

…especially in the face of evidence for the therapeutic value of testosterone for women that’s been available since 2001 (date of revised edition) in a book like MD Elizabeth Lee Vliet’s 600+ page “Screaming To Be Heard”, Hormone Connections Women Suspect but Doctors Ignore".

Also, in the face of the data that’s been collecting dust since at least 1939 (THIRTY-nine) for the therapeutic value of T for women (see, for example, hostile-witness John Hoberman’s historical recount of TRT, his 2005 “Testosterone Dreams”, pages 83, 84.

For a personal anecdote, just ask my wife of 42 years, who was born with Lifelong, Generalized Hypoactive Sexual Desire (meaning, essentially, “zero need/urge/hunger for sex”; no libido), for whom a prescription for testosterone finally gave her what she’d long lamented she was missing, being able to enjoy th’ ice cream as she’d observed most everyone else enjoying it through her life.

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Thanks for sharing your experience, much appreciated!

That’s great, glad to hear it!

I think this explains it, but it’s not as fun as government conspiracies

All of these studies are important sure, but the one thing that bothers me to this day is that the body is a system with many parts. The brain keeps the body and its parts in homeostasis as you age. Once you start introducing elements into the system that aren’t natural you then take the risk of throwing something else off. It’s an intricate and well controlled process that has evolved over thousands of years. It’s a real concern honestly that many people don’t think about because they’re too focused on these studies and instant benefits. This is why I think physicians who don’t work in a trt clinic are so cautious about placing patients who are low normal on trt because they know how the body works and if you’re eating healthy and exercising and doing all the right things, sometimes it’s best to just let the system run on its own. It’s funny how some members on here are throwing big pharma under the bus, but clearly they’re still profiting from these testosterone prescriptions especially with the newly patented versions of test and will continue to do so as trt clinic pill mills continue to grow and thrive. The physicians at these clinics (they are NOT hormone doctors, usually internal medicine), are also profiting heavily and most of them don’t practice what they preach. It’s laughable really the whole thing. So there are two sides to this and I’m all for trt but I think it’s overprescribed currently. I personally hope the fda cracks down on these clinics soon because they’re causing more harm than good imo.

Actually TRT is under prescribed for those that actually need it. The university of Miami published a study showing 20 percent of men between adolescence age and up to 39 years old are suffering from low testosterone.

Only small percentage of these men are actually being treated with TRT. You’re probably right about one thing though, it’s overprescribed for men that don’t need it.

I believe if people want to optimize their hormones for longevity, they should have that right to do so, but responsibly and safely.

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TRT is safe, there’s little debate within the current consensus as to whether legitimate trt (say aiming for mid to upper portion of the ref range) is safe or not

There are obvious contraindications… like having androgen receptor responsive subtypes of cancer.

However when this forum talks about ‘trt’ many (including erronously myself in the past) have touted higher dosages as being appropriate for long term use.

If your nadir 6 days post shot is 1200ng/dl… that is not TRT, and the jury has yet to come to a consensus regarding long term prognosis.

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20 percent sounds kind of high. I’d like to see that study if you don’t mind. Thanks for your response.

Testosterone deficiency has a prevalence of 10%-40% among adult males, and 20% among AYA men aged 15-39 years, he added. Therefore, Lokeshwar and colleagues hypothesized that serum total testosterone levels will decline in AYA men.

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This is something I see way too commonly on trt forums; men with low testosterone, coupled with all the symptoms that come with it, and yet their doctor or endo won’t prescribe testosterone for some vague or irrational reason. I don’t get why physicians seem so anti-testosterone.

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For the same reason physicians are absurdly reluctant to prescribe painkillers nowadays, going as far as to refuse post operative use.

Testosterone, like painkillers has been subject to abuse

As a result regulatory bodies have cracked down so hard, those who legitimately require trearment may be turned away because the doctor worries about getting audited.

With testosterone there’s also a lack of education, however what i’ve said still stands.

Testosterone replacement is like pain management… very risky for the doctors, even though it shouldn’t be.

Cracking down on legal, legitimate avenues doesn’t solve the problem associated with illicit use… the process of thought that led to punishing doctors and patients to deter black market use has me dumbfounded… so… so stupid…

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I don’t disagree with your underlying argument at all, but to this specific point: surgery has changed. Many common procedures can be performed less invasive it, with reduced trauma, lower gas pressures, and shorter times under anesthesia; these factors tend to result in reduced post-operative pain. If you don’t need a narcotic, it’s best not to take a narcotic you know?

To un-derail, I think it’s fair to say that thought process can swing too broadly and we stop prescribing any therapeutics for non-life-threatening conditions.

I can’t think of many surgeries that don’t involve fairly extensive postoperative pain

Even arthroscopic surgery can be quite painful

If you’re having a meatoplasty or minor surgery… you would be correct. I had a cystoscopy… there’s no need for anything aside from paracetamol to treat discomfort associated with that.

Open shoulder surgery to repair multiple tears and cut/re attatch bicep tendon… I had a PCA and was sent home with 7 days worth of narcotics… It was necessary because that procedure was painful

If you are having arthroscopic rotator cuff repair (I has open surgery, hurts a lot more), hardware put in for broken bones, hernia surgery, teeth removed etc

Chances are you’ll need narcotics in the first 2-3 days

Contrary to popular belief… you aren’t going to ger addicted from a script of say… 15 -20 vicodin tablets

You could say "but only the most severe pain requires narcotics’
This isn’t true. Uncontrolled postoperative pain leads to inferior outcomes, there is a huge body of data covering this topic

Can even lead to chronic pain. If the pain is going to be consistently higher than say… a 5/10 post operatively (no one can sleep with a constant 5/10+)… just take the narcotics

They aren’t the boogeymen the media makes them out to be so long as you aren’t chasing a high.

America is participarly squeamish over this due to the opiate epidemic… but opiate addiction seldom stems from legitimate use for post operarive pain… or chronic pain…

Addiction stems from prescribing too much, prescribing inappropriately… and the biggest variable… addiction stems from people stealing meds, selling meds on the street etc.

Most addicts become addicts through illicit use… not licit use.

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