Umm itchy sore and sore nipples aren’t when you dose adex. It should be taken throughout cycle to combat other high estrogen effects and as a gyno preventative. My BP went through the roof at an E2 of ~70 and almost quit TRT before I got adex and dosed appropriately to keep my E2 at 20-30. On 500mg/wk, I take 0.5mg EOD to keep within that range too.
Good thread on high E2 effecting gains, which is counter intuitive of cycling to begin with:
High E2 may also kill your sex drive; that sounds fun…