High SHBG Protocol Advice?

When SHBG is high there is a lot of non-bioavailable SHBG+T that inflates TT so it overstates your T status. You need to inject a lot more T and high TT then needs to be disregarded and you need high calculated FT.

E2=80 pmol/L is your target. As you ~double FT E2 will rise too. You will probably need 0.5mg anastrozole twice a week at time of twice a week injections.

Thyroid is a mess. TSH should be near 1.0
fT3 is good at mid-range
fT4=14.4 is below midrange=17 suggesting lack of iodine. Iodine deficiency in UK is very common as iodized salt is only found in a few shops. So your problem may be simple iodine deficiency.

Eval overall thyroid function via oral body temperatures - see below. With your fT3 we expect good body temperatures, TSH suggests that they will be low and we suspect elevated rT3 as the cause. If temperatures are low, read the thyroid sticky noting references to rT3, stress, adrenal fatigue, cortisol and Wilson’s book.

We do expect to see elevated rT3 with low T and low thyroid function when training as that is technically over-training and stressful. However, that is mostly noted with young guys who overcome lost natural energy with adrenalin - until their adrenals get weak.

MCV is high end. Do you have digestive issues or food allergies/sensitivities? Mean corpuscular volume - Wikipedia

CK is high which can be muscle damage. Do some research.
Start here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507674/

Blood pressure and pulse? How changing?

Are you using a statin drug? Can cause above and perhaps a chronic low level cough.


Please read the stickies found here: About the T Replacement Category - #2 by KSman

  • advice for new guys - need more info about you
  • things that damage your hormones
  • protocol for injections
  • finding a TRT doc

Evaluate your overall thyroid function by checking oral body temperatures as per the thyroid basics sticky. Thyroid hormone fT3 is what gets the job done and it regulates mitochondrial activity, the source of ATP which is the universal currency of cellular energy. This is part of the body’s temperature control loop. This can get messed up if you are iodine deficient. In many countries, you need to be using iodized salt. Other countries add iodine to dairy or bread.

KSman is simply a regular member on this site. Nothing more other than highly active.

I can be a bit abrupt in my replies and recommendations. I have a lot of ground to cover as this forum has become much more active in the last two years. I can’t follow threads that go deep over time. You need to respond to all of my points and requests as soon as possible before you fall off of my radar. The worse problems are guys who ignore issues re thyroid, body temperatures, history of iodized salt. Please do not piss people off saying that lab results are normal, we need lab number and ranges.

The value that you get out of this process and forum depends on your effort and performance. The bulk of your learning is reading/studying the suggested stickies.