High SHBG on TRT

How has IGF-1 responded to sermorelin? Does not work for some people.
Sublingual may be absolutely ineffective.

Please post your lab work with ranges. Not just hormone levels.

0.25mg anastrozole is inadequate for most guys in 100mg T per week and more would be needed for 140mg/week.

Your E2 may be high and higher E2 typically leads to more SHBG.

Please read the stickies found here: About the T Replacement Category - #2 by KSman

  • advice for new guys - need more info about you
  • things that damage your hormones
  • protocol for injections
  • finding a TRT doc

Evaluate your overall thyroid function by checking oral body temperatures as per the thyroid basics sticky. Thyroid hormone fT3 is what gets the job done and it regulates mitochondrial activity, the source of ATP which is the universal currency of cellular energy. This is part of the body’s temperature control loop. This can get messed up if you are iodine deficient. In many countries, you need to be using iodized salt. Other countries add iodine to dairy or bread.

KSman is simply a regular member on this site. Nothing more other than highly active.

You are better off with steady T levels from frequent injections.