From article: When humans are exposed continuously to hypoxia, they develop adaptative mechanisms that are far more efficient than those observed in newcomers.50–53 These long-lasting mechanisms include anatomical (wider chests, shorter and lighter bodies, etc), embryological (smaller fetus and placentas), circulatory (improved maximum flow output and higher pulmonary arterial pressure) and respiratory adaptations (improved hypoxic ventilatory response and oxygen diffusion capacities).52 54–56 Chronic exposure to hypobaric hypoxia leads to the development of more subtle compensatory mechanisms. These factors include long-term erythrocytosis, angiogenesis, capillary remodelling and an improved ventilatory response57–60 (figure 2).