ELS No, I’m positive they weren’t there.
BUDS Thanks. I just wanted to get opinions from the people here that I trust. Having never been through this I wanted more opinions than just my own. Letro shipped out today, express. Hopefully I’ll have it tomorrow and start on that. I’m sure I will be fine. It’s still very small and I assume following this protocol will keep it that way.
Man that sucks lol. Nothing to add, just wishing you luck.
don’t panic mate, you can get rid of gyno fairly easily
Not panicking at all. I know I caught it early and I’m getting on top of it as quickly as possible. I just wanted everyone’s opinion since its a new road for me.
Thank you though. The reassurance is appreciated.
[quote]BUDs wrote:
[quote]eatmorefood wrote:
I’m running Prami at 1mg/day. It’s estrogen related. I’m sure the TNE caused unstable levels. I’ve ran that before without issue. I’ll be taking Adex at .5 daily until the Letro gets here. Strange thing is I don’t feel any estrogen sides either. Furthermore nips aren’t puffy, itchy, they were slight;y sensitive yesterday which is what made me check for a mass. It is certainly there and I’m positive its early stage gyno. On a positive note upon waking the nips aren’t sensitive. Masses are still there but I think all should be good.[/quote]
I’d up the adex like your doing and and some Nolva until you get the letro[/quote]
A-dex reduces the blood levels of Nolva significantly. again, part of why i said to use Ralox here…
I was aware of the interaction. I didn’t know how much it reduced it but I took my .5 of Adex and 60mg nolva. Kinda figuring even if it reduces it something is better than nothing until I receive the Letro. Ideally the Letro shows up tomorrow. It would take longer to ralox at this point than the the letro. So unless letro fails I wont go that route. Cutting out the TNE (which I did of course) will most likely stop any growth IMO. So everything else is just insurance at this point.
[quote]cycobushmaster wrote:
[quote]BUDs wrote:
[quote]eatmorefood wrote:
I’m running Prami at 1mg/day. It’s estrogen related. I’m sure the TNE caused unstable levels. I’ve ran that before without issue. I’ll be taking Adex at .5 daily until the Letro gets here. Strange thing is I don’t feel any estrogen sides either. Furthermore nips aren’t puffy, itchy, they were slight;y sensitive yesterday which is what made me check for a mass. It is certainly there and I’m positive its early stage gyno. On a positive note upon waking the nips aren’t sensitive. Masses are still there but I think all should be good.[/quote]
I’d up the adex like your doing and and some Nolva until you get the letro[/quote]
A-dex reduces the blood levels of Nolva significantly. again, part of why i said to use Ralox here…
[/quote]
Pretty sure it’s the other way around. And I believe it only reduces around 30% so upping the dose up enough you’ll make up for it.
I’ve gotten lumps before, puffy nips before and have done this before I got letro and everything worked out just fine. Just speaking from experience.
Thanks to everyone. The advice and support is much appreciated. I will continue the adex and nolva until the letro arrives and update as things progress… Or don’t progress as the case may be.
[quote]BUDs wrote:
[quote]cycobushmaster wrote:
[quote]BUDs wrote:
[quote]eatmorefood wrote:
I’m running Prami at 1mg/day. It’s estrogen related. I’m sure the TNE caused unstable levels. I’ve ran that before without issue. I’ll be taking Adex at .5 daily until the Letro gets here. Strange thing is I don’t feel any estrogen sides either. Furthermore nips aren’t puffy, itchy, they were slight;y sensitive yesterday which is what made me check for a mass. It is certainly there and I’m positive its early stage gyno. On a positive note upon waking the nips aren’t sensitive. Masses are still there but I think all should be good.[/quote]
I’d up the adex like your doing and and some Nolva until you get the letro[/quote]
A-dex reduces the blood levels of Nolva significantly. again, part of why i said to use Ralox here…
[/quote]
Pretty sure it’s the other way around. And I believe it only reduces around 30% so upping the dose up enough you’ll make up for it.
I’ve gotten lumps before, puffy nips before and have done this before I got letro and everything worked out just fine. Just speaking from experience.
[/quote]
yup, you’re right. possibly letro, too:
: Br J Cancer. 2001 Aug 3;85(3):317-24. Links
Pharmacokinetics of anastrozole and tamoxifen alone, and in combination, during adjuvant endocrine therapy for early breast cancer in postmenopausal women: a sub-protocol of the ‘Arimidex and tamoxifen alone or in combination’ (ATAC) trial.Dowsett M, Cuzick J, Howell A, Jackson I; ATAC Trialists’ Group.
CRC and UCL Cancer Trials Centre, University College London, Stephenson House, 158-160 N Gower Street, London, NW1 2ND, UK.
The ATAC trial evaluates in a randomized, double-blind design, Arimidextrade mark (anastrozole) alone or in combination with tamoxifen, relative to tamoxifen alone as 5-year adjuvant treatment in postmenopausal women with early breast cancer. Patients included in the pharmacokinetic (PK) sub-protocol had been in ATAC for > or =3 months, taking their medication in the morning and were 100% compliant for the preceding 14 days. Blood samples were collected 24 +/- 4 h after last dose. Trough (C(min)) plasma concentrations of anastrozole, tamoxifen and desmethyltamoxifen (DMT) were measured by validated methods. The PK results were based on a total of 347 patients (131 anastrozole (1 mg o.d.), 111 tamoxifen (20 mg o.d.), 105 anastrozole and tamoxifen (1 and 20 mg o.d. respectively)). The geometric mean steady-state trough plasma concentrations of tamoxifen and DMT were statistically equivalent in patients receiving tamoxifen alone or in combination with anastrozole: geometric mean tamoxifen = 94.8 ng ml(-1)and 95.3 ng ml(-1)in tamoxifen alone and combination groups, respectively; geometric mean DMT = 265.1 and 277.6 ng ml(-1)in the tamoxifen and anastrozole and tamoxifen groups, respectively. The geometric mean anastrozole levels were 27% lower (90% Cl 20-33%;P< 0.001) in the presence of tamoxifen than with anastrozole alone. Baseline plasma oestradiol levels were not obtained in the PK sub-protocol, however, such information was available from a similar ATAC sub-protocol, which evaluated bone mineral density. Mean oestradiol levels were 21.3, 19.3, and 21.6 pmol l(-1)prior to treatment and 3.7, 20.9 and 3.6 pmol l(-1)after 3 months in the anastrozole, tamoxifen, and combination groups, respectively (n = 167). On-treatment values were below the detection limit (3 pmol l(-1)) in 43.6 and 38.5% of the anastrozole alone and anastrozole in combination with tamoxifen groups, respectively. As a result of (a) the lack of effect of anastrozole on tamoxifen and DMT levels and (b) the observed fall in blood anastrozole levels having no significant effect on oestradiol suppression by anastrozole, we conclude that the observed reduction in anastrozole levels by tamoxifen is unlikely to be of clinical significance when anastrozole and tamoxifen are administered together. Copyright 2001 Cancer Research Campaign.
it has a more significant impact on letrozole metabolism
1: Biopharm Drug Dispos. 2006 Aug 15;27(7):335-344 [Epub ahead of print] Links
The effect of tamoxifen on the pharmacokinetics of letrozole in female rats.Tao X, Brodie AM, Nnane IP.
Temple University School of Pharmacy, Philadelphia, PA, USA.
The effects of single doses of tamoxifen (TAM; 0.5-5 mg/kg, i.v.) and chronic pretreatment with TAM (0.1-5.0 mg/kg/day, i.p. for 7 consecutive days) on letrozole (0.5 mg/kg, i.v.) pharmacokinetics were evaluated in female Sprague-Dawley rats. The plasma concentration-time profiles of letrozole (0.1-2.0 mg/kg) after single i.v. doses were analysed by the non-compartment model with terminal half-lives (t(1/2,lambdaz)) ranging from 34.3 to 37.5 h. The volume of distribution at the terminal phases (V(d(lambdaz))) ranged from 1.9 to 2.1 l/kg and clearance (CL) varied from 0.036 to 0.042 l/(h.kg). After co-administration of TAM and letrozole intravenously, the t(1/2), V(d(lambdaz)) and CL of letrozole were not significantly altered. Chronic pretreatment with TAM significantly decreased the t(1/2) of letrozole by about 33%, and increased its clearance by an average of 40%. However, TAM pretreatment did not significantly affect the V(d((lambdaz)) of letrozole in female rats. Co-administration of letrozole and TAM orally increased the absorption half-life of letrozole threefold although the absolute bioavailability remained unchanged. These observations suggest that single oral doses of TAM delay the absorption of letrozole while chronic pretreatment with TAM accelerates the elimination of letrozole, probably due to induction of cytochrome P450 enzymes in rats. Copyright (c) 2006 John Wiley & Sons, Ltd.
Letro arrived. Started the protocol in the gyno sticky. Dropped the nolva. Still took .5 of adex.
I will update this as things show improvement.
Thanks again everyone.
A few days in. No improvement. Not that I expected it. I figure it will be a couple of weeks to improve but just wanted to update. Things have not gotten any worse. I’m sure dropping the TNE stopped the progression but I have no scientific proof. Nips are not sensitive in any way. Looking to the future I’m sure all will be well.
I know letro has to somewhat in a way build up in your blood.
Hope things will get better here shortly