Extremely High SHBG, Feel Horrible, Please Help

TSH should be closer to 1.0, you might be under medicated. Please see last paragraph in this post.

Do you feel cold easily?
Are your outer eyebrows sparse?
What has been your life time history of [not]using iodized salt?

Can you post TSH, T3, T4, fT3 fT4?
fT3 is the active hormone and should be tested!
Some on T4 meds do not do well because they have poor fT4–>fT3 conversion.

TRT with high FT levels will help reduce SHBG, but SHBG can be slow to fall.

Should test LH and FSH as FSH can be a better measure of LH than LH itself because LH change rapidly.

High SHBG is lowering FT creating non-bioavailable SHBG+T which inflates TT and then TT overstates your T status.

SHBG can be increased by high E2 [not you], low FT or livers conditions/disease.

“SHBG levels increase with estrogenic states (oral contraceptives), pregnancy, hyperthyroidism, cirrhosis, anorexia nervosa, and certain drugs. Long-term calorie restriction of more than 50 percent increases SHBG, while lowering free and total testosterone and estradiol”

Both low-T and suspected thyroid issues could be contributing to your issues.

Please read the stickies found here: About the T Replacement Category - #2 by KSman

  • advice for new guys - need more info about you
  • things that damage your hormones
  • protocol for injections
  • thyroid basics
  • finding a TRT doc

Evaluate your overall thyroid function by checking oral body temperatures as per the thyroid basics sticky. Thyroid hormone fT3 is what gets the job done and it regulates mitochondrial activity, the source of ATP which is the universal currency of cellular energy. This is part of the body’s temperature control loop. This can get messed up if you are iodine deficient. In many countries, you need to be using iodized salt. Other countries add iodine to dairy or bread.

KSman is simply a regular member on this site. Nothing more other than highly active.