[quote]rainjack wrote:
Electric_E wrote:
Ok great cheers.
Personally I take all word of mouth and anecdotal information with a big pinch of salt until I can find somethign of substance to back it up.
That’s going to be a tall order. The chemicals in question are used mainly to treat female breast cancer. There’s not going to be much scientific data on their use in healthy adult males.
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Very true, in this case though it is not crucial as the effects on lipid profiles with certain AI’s is not a matter of life or death.
It is difficult to even achieve any definitive anser even fromother people experiences, as you would need a lot of people to follow the exact same AAS course and diet twice whilst using different AI’s each time just to get an idea of the effects caused, which is why I take take it with a pinch of salt when someone says that a certain AI increased cholesterol becuase it is very difficult to stick to the controlled conditions required to do this.
It might be tough to quantify anastrozole’s negative impact on lipids compared with exemastane’s; so I agree its hard to have a controlled environment so your pinch of salt might be fine and dandy.
Be cautious using phrases like matter of life and death though. If you have a pre-existing lipid condition and the combination of gear and AI’s negatively impact an already poor situation it could actually become a matter of life and death.
Yeah its the reason exemastane is recommended over anastrozole if that factor concerns you. Having said the above, it is true that after a few months my cholestrol moderated itself back to baseline[/quote]
How long did it take for your cholesterol to moderate itself? You see, I started taking arimidex back in December of 2007 (about 7 months ago). I got a blood test in February and the cholesterol was dramatically changed (my prior lipid was fine). I got one again last week. It was a little bit “better” but still slightly off.
Now, I don’t believe all the bullshit we’re being fed about cholesterol. Apparently tricgylcerides are the indicator we should be looking at, and my tricglycerides are fine. However, I did apply for some insurance recently, and they wanted to charge me a whole lot for the premium because of this cholesterol number. So, I am looking to bring my cholesterol back to a point that makes the powers-that-be happy.
I had the same thing with New York Life, its the reason I started Lipitor years ago.
Hard to say. My first cholesterol test post a-dex was 3-4 months after I discontinued its usage. So as a vague answer I’d say you could be fine within less than 3 months? Sorry for the lack of precision
[quote]saps wrote:
It might be tough to quantify anastrozole’s negative impact on lipids compared with exemastane’s; so I agree its hard to have a controlled environment so your pinch of salt might be fine and dandy.
Be cautious using phrases like matter of life and death though. If you have a pre-existing lipid condition and the combination of gear and AI’s negatively impact an already poor situation it could actually become a matter of life and death. [/quote]
Fair point about the life and death aspect of raised cholesterol levels, I meant for me personally it is not an immediate concern, but you are right it could become that way.
Also going back to what RJ mentioned about most medical/scientific information on the internet regarding AI’s will mostly relate to a woman�??s usage, if adex raised cholesterol in men using adex for BB purposes, then I see no reason why adex would not raise cholesterol in women using it, but yet I cannot find any medical data relating adex to increased cholesterol.
Interesting Point EE
One thing to keep in mind is the relationship [in a man] between cholesterol and testosterone. Since woman has so much less test perhaps they impact is less. I am totally speaking out of my ass now but that is something that is curious.
What is A-dex impact on women’s cholesterol? I’m sure there are studies out there
And it appears there is good evidence to suggest that Asin (as reported by other members) does not have the same negative effects on lipids as adex.
So now we have the scientific and the “word of mouth” experience from other users, I will research more n asin protocol and will most probably use that for my next ccyle instead os adex.
Aromasin is a steroidal AI. It acts by binding with the aromatase enzyme – permanently, not competitively. Hence the name ‘suicidal aromatase inhibitor’. Until the body recycles the existing bound enzymes, similar to what occurs with carbon monoxide and haemoglobin in red blood cells, the actual capacity for conversion is reduced.
While there may be a benefit with regards to lipid profile, the primary reason it’s better is that it prevents estrogenic rebound when discontinued, unlike arimidex and letro. That estrogenic rebound can be responsible for much of the mood lability, erectile (dys)function and loss of libido associated with the post-cycle period.
Also, at the dosage used by most men (<=6.25mg/day), it causes significant, but not total suppression of estradiol formation. While much decried in the AAS using community, estradiol is important for bone density, anabolism, immune function, libido, and more. Reducing it to non-measurable amounts often results in negative side effects.
Letro makes sense when attempting to possibly reverse existing gynocomastia, but arimidex simply fails to compare favorably with aromasin. You’re paying serious money for the AAS you use, why wouldn’t you buy the best AI you can?
FWIW: I have been using about 1500mg/week of gear for 5 weeks and only using 6.25mg/day aromasin. I have had no issues at all with gyno and plan on dropping the dose to 6.25 eod. This combined with the previously stated benefits of healthier lipid profiles has lead me to consider completly phasing out adex altogether. An extra $20 a bottle is worth it from a health standpoint IMHO.
