E2 Management Help

Dissolve anastrozole in vodka 1mg/ml and dispense by volume or by the drop. When you make a dose change it takes a week for the effect to be realized in terms of anastrozole serum levels and E2 levels. So you can’t make short term changes. Do not be handcuffed by 1/2mg or 1/4mg increments.

Guessing 120mg T per week.
Suggest that you take anastrozole only on days of T injections, adjust the dose. Things would be smoother with injections twice a week or E3D. Inject SC over upper legs with #29 1/2" 0.5ml insulin syringes.

You are not the first with problems getting balanced on low SHBG. SHBG can be low from high FT which low SHBG can provide, or from diabetes.

Please report labs with ranges.

E2 levels are inversely and linearly proportional to anastrozole dose.

As for what dose and what E2 and fE2 levels; you need to work that out yourself.

This is your 4th topic. I will repeat standard material below in case you have not seen before.

Please read the stickies found here: About the T Replacement Category - #2 by KSman

  • advice for new guys
  • things that damage your hormones
  • protocol for injections
  • finding a TRT doc

Evaluate your overall thyroid function by checking oral body temperatures as per the thyroid basics sticky. Thyroid hormone fT3 is what gets the job done and it regulates mitochondrial activity, the source of ATP which is the universal currency of cellular energy. This is part of the body’s temperature control loop. This can get messed up if you are iodine deficient. In many countries, you need to be using iodized salt. Other countries add iodine to dairy or bread.
Please report doses in mg’s and iu’s, not volumes.