The major bark components are fat-soluble compounds. Triterpenes are present (14%), including ursolic, oleanolic, and crataegolic acids. The lipid fraction contains fatty acids, which are 12 to 24 carbons in length. The ferulic acid esters are bound to n-tetracosanol and n-docosanol.6 N-docosanol has been used in some commercial products.6 Phytosterols present in pygeum include beta-sitosterol, beta-sitosterone, and campesterol.4, 5, 6, 8 Tannins have also been found in the plant.4 The highest activity is in the lipophilic extracts of the plant; these extracts are standardized to contain 14% triterpenes and 0.5% n-docosanol.6
Its benefits in BPH may be due to an ability to prevent the binding of dihydrotestosterone in the prostate gland and/or inhibit 5-alpha reductase and aromatase.3 Other proposed mechanisms include inactivation of androgen receptors via blocking of nuclear translocation; inhibition of cellular growth factors; anti-inflammatory activity via inhibition of 5-lipoxygenase; increases in bladder elasticity; histological modification of glandular cells; and inhibition of prolactin levels and consequently blocked accumulation of cholesterol in the prostate.2, 5, 10
The ferulic acid ester components are responsible for pygeum’s endocrine system activity. N-docosanol reduces leutinizing hormone, testosterone, and prolactin levels. Accumulation of testosterone within the prostate and subsequent conversion to the more potent form (dihydrotestosterone) is believed to be a major factor in prostatic hyperplasia. The phytoestrogenic action of P. africana extract markedly reduces the volume of prostatic hypertrophy.12 Fat-soluble components reduce cholesterol content in the prostate as well, decreasing accumulation of cholesterol metabolites.6
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It looks like this applies as an anti-androgen. You can find more specific forms of these for hair.
This review shows this lowering cholesterol (sterols), testosterone and prolactin (ferulic acid) and possible downstream androgen inhibition. This sounds riskier for extra side effects than simply blocking DHT or androgen receptors locally.
I have the same sensitivity issue have you found anything to resolve it. Also I found that my skin on my D has changed like it’s very dry so dry that when I have sex it hurts the girl. Also I’ve developed super dry skin in my fingers and it’s also most like my fingers are crusting away. I’m not sure if this is a side effect of testosterone
That’s definitely a possibility. But in theory if it is your E2 rising what is your plan to take cate of that do you plan on talking a A.I because I guess from what I read on this forum it’s not the best thing to take. Idk I have been struggling with this for a while and it definitely effects sex becuase I can’t feel everything
That’s the thing I have been on TRT going on 4 years. And have had my ups and downs with sensitivity but for the most part it’s been extremely decreased.
Yea I can try a low dose cialis but for the most part it helps with errections but not so much with sensitivity.
Restoring my sensitivity is a huge struggle for me and I don’t know what about TRT deceased it
Your doc prescribes Fin because its Hollywood. People are vain. Im on the other side in Malibu, and plenty of good hair and bald dudes, Fin is very popular. I have friend who is not concerned but aware of his lack of sex drive, and he’s told me about the countless women that simply dont do anything for him. He just thinks that he’s getting older, but hes been like that since he was in his late 30s. Makes lots of money, and is more concerned with not dating gold diggers. Im sure he can perform, but poorly.
A study I read, had roughly 15% of the test subjects report sexual disfunction. However, something like 7-8% of the placebo group reported sexual disfunction.
I would say if we subtract the placebo group from the finasteride group we would get close to what percent actually have sexual disfunction on the drug, which would be 7-8%.
Having sexual dysfunction isn’t really the issue IMO. It’s the whole it doesn’t get better when you stop taking it thing that is the issue. I’d guess less than 1% are in that category though, for better or worse I suppose
I’m surprised it took this long for someone to ask this question. The reason is because I already know what he would say or at least I can make an educated guess and his response wasn’t the one I was looking for. He obviously doesn’t think that Finasteride and Dutasteride are as dangerous for you as so many people think because if he did, he wouldn’t prescribe it to so many patients. Somebody’s response above touched on this specially where he said that it’s not taken seriously by the medical establishment because there’s no real way to define it. Another said a lot of good doctors don’t believe it’s as dangerous as a lot of people feel and wait to see if there are side effects and then they either lower the dosage or stop it altogether at that point. So if I asked him that he would have a great answer explaining why it’s overblown and that they are simply side effects that are possible with all medications. If you aren’t having those side effects then you are safe to use it, would be my guess as another thing he might say. So had I asked him first, I still would have came here and asked the same question. It would have been stated a little differently where I would have told you guys what my doctor said specifically and then asked how can an experienced, very knowledgeable and well respected doctor in this field feel this way when there is such a large population of people who feel its extremely dangerous? Now that doesn’t mean asking my doctor is a waste of time because finding out exactly how he feels would be good information to have, but again, I would still wonder why so people warn others to never take the medication.