120 mg pseudoephedrine combined with 300 mg caffeine alters epinephrine and free fatty acid concentrations in the blood according to Doug Kalmans article but to get the same fat loss results as 20mg of ephedrine with 200mg caffeine is the pseudo+caffeine dose above equivalent? What protocol would produce similar results?
Great question Topkat. The metabolic activity of pseudoephedrine is different that it’s chemical brother (isomer, actually) ephedrine. It is important to realize and understand the following:
the 1R,2S-ephedrine is the most potent of the 4 ephedrine isomers (1R,2S has nearly equal effects on beta1& 2 receptors and some effect on beta-3 receptors). The rank including pseudoephedrine is 1R,2S ephedrine followed by 1R,2R ephedrine, followed by 1S,2S-pseudoephedrine and finally 1s,2R-pseudoephedrine.
In the Ma Huang plant the content is ranked l-ephedrine making up 50-90% of the alkaloids within the plant with the rest being d-psuedoephedrine, l-norephedrine, d-norpseudoephedrine,1-N-methylephedrine and d-N-methylpseudoephedrine.
Research demonstrates the l-ephedrine and nor-ephedrine to be useful for weight loss with no long term studies on pseudoephedrine - so in essence this is the best answer thaT I can give you.