Yes.
No significant changes in serum lipids were observed in patients treated with aromatase inhibitors in the first-line setting.
For the fact the second one reported a change in lipids tells me the first one has holes in the data.
In this day and age I would like to have multiple studies showing the same thing, or at least the majority of studies saying the same thing.
I believe this to be true, that is most men are <1 mg anastrozole per week.
As per previous link:
it is suggested that the blood lipid levels should be regularly assessed in patients with long-term anastrozole treatment.
Time will tell I guess. I will update my journey here.
After all is Said and done, People Will realise that ai wasnt such a bad idea anyway and then we back at Square one
I wondered about this. If a tissue is missing the e2 it needs, would not the e2 in serum flow to that tissue eventually and be able to help?
I think now that is correct. I think early on the AI dose was higher. 1 mg tabs is the standard for the pill.
I am guessing (and based on reading forums a few years ago) that early on dosing was higher. I think 1 mg per 100 mg of T was a guideline (however stupid that sounds), and it was mentioned on this site a lot. I think some of that is probably to blame for the no AI crowd now.
I think that if it was microdosed from the early days of TRT, that maybe it wouldnāt have gotten all the hate it does now.
If my options were 1 mg of adex a week or none, Iād take the latter. Obviously a false dichotomy, but I think doctors did Rx that, and patients followed it.
Bone density, cholesterol, blood pressure, heart rate can all be symptoms of a declining CV due to not enough E. So much more we cannot even track though, for example the Armotase in the brain is unknown. Other organs and areas. Itās literally everywhere.
More than likely AI guys will find a different excuse as to why these might be declining in health and never blame ai (a drug created or woman breast cancer 
). Ive seen it a dozen + times here and when they got off AI everyhitng from extreme anxiety to cholesterol and heart rate all resolved.
Obviously there could be genetic issues that excacerbate these markers.
More dishonest bias. What about the times it did not? You guys donāt even follow up to the one and done posts, you donāt know. Here is just one case:
I mean moral of the story is not to crash or lower E2 to an unfavorable level, everything else you guys keep repeating over and over is all hypothetical hog wash.
Iām nearly embarrassed to say this, but when I started TRT I took up to 4mg weekly of Anastrozole. I was terrified of e2 from earlier gyno (removed). I surmise the HCG was the only thing keeping me from feeling like absolute garbage during this time. Anyway, now I know better, and thatās partly from the āNo AIā crowd, so I have to give them that
Yeah, but what is āenoughā e2? I agree some is better than none, and studies back that up. But I donāt think anyone is arguing against that here. Is the idea that since we donāt know what āenoughā is (yet) that thereās no point messing with it out of caution?
You are the only one who has acknowledged this thanks.
How much is not the right question. When you give the body T, without supressing E, you are not causing harm. You just might not be optimal. This is all about harm reduction. Which is health for a man on TRT.
Ive stated this so many times, and i know you heard me, but ill say it again for others to read.
The reality of E is that our body creates what it needs, and only those with specific genetic or health disorders can argue that it does not for them. We are not talking about those people and i have no clue what to tell those folks.
When we block E, we could be causing serious harm to the heart, brain, bones and etc. Its simply not worth the risk.
Why is an AI so bad?
We cannot measure E in many areas of the body because it is a paracrine hormone ( 1. relating to or denoting a hormone which has effect only in the vicinity of the gland secreting it.) the brain and bones and etc.
We are only measuring part of our E2 when we run labs and take an AI.
We might be suppressing the E in our heart, and your E levels might seem great on a lab, but the heart is deadly low on this cardio protective hormone.
I donāt know about everyone else, but this scares the shit out of me.
Eventually lipids, heart rate, and other issues arise, and the man thinks he might be needing a diet change or whatever else. Maybe they start on statins. Never realizing that their heart, bones and etc are lacking E.
Simple solution: new trt patients should Simply modify the dose and frequencyā¦ And give it time.
Anyone who takes an AI can go ahead and take 1mg if they want. I wont argue with them. I will however explain why im against an AI, and why i tell new guys on TRT to avoid it at all costs.
You are the only one who has acknowledged this thanks.
You ever get tired of being so dishonest?
I Love My ai. High estrogen is total shit,.never ever worked for me.
My god you got some serious issues. You are behaving so emotional, you cannot even take a discussion with someone who 100% disagrees with you, while you switch topics and focus of the topic.
Come up with your own material and donāt self project my man.
Lolwut? Everyone in this thread would agree you are the weird One. You have mental issues and it is painfully obvious. Your high e2 is making you behave in a very very weird Way, get Lost already or jump on that AI so you start acting like a normal male.
You notice how many points he has down right ignored cause he has nothing? He thought this would be a walk in the park like it would have been most likely at some point when the E2 loving brigade took hold of these forums.
Hey @Carma, how are you doing? So I looked this up and it appears I would need to spend $795 and attend Nealās BHRT Part I in order to access the forum.
So I would be a laughing stock for spending $795 to peruse a forum full of men (hey you left out the ladies 
) without any real knowledge of the medical literature? A generous chap shared a sample screenshot of quality over there. Nevertheless, I try to be helpful. I am willing to consider posting over there if you guys comp me. So far I donāt see the business case for $795 spend.
Been at 150-160 mg a week of T again in one shot. Taking around 0.25mg of arimidex a week. Waking up with erections, sleeping good, not much brain fog.
Tried 0.125mg only big no, tried E4D better but still kinda iffy. Kind of now bouncing between 0.25mg a week by taking 0.125mg twice or slightly more in taking a dose in 3 days.
Lol these guys seriously are narcissistic. No wonder they get so angry on any other forums where people donāt just follow them blindly.
