@unreal24278 it all begins with serotonin. Yes deca and tren and test also affect the dopamine receptors in the brain, but serotonin ironically has a larger affect on mood and libido. After deca at times the body compensates by pumping more serotonin out which creates an even bigger issue. It’s all about the balance. It’s why when people try to combat these issues with more drugs it only sets the goal line further back.
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Thank you for the explanation, I’ve learnt something new. Howevs isn’t the effect on dopamine from test different to that of nand? Overall, test tends to increase dopamine (yay) and nandrolone tends to decrease it (nooo)
Or is unreal24278 confused?
@unreal24278 this is where the body gets tricky. As the body always wants homeostasis - when you keep giving your body more and more dopamine, the body responds by decreasing sensitivity.
This is true to some degree in regards to the increase of androgen receptors on test. The assumption would be that more test equals more receptors equals more gains. That works for a time. The body will decrease the sensitivity of these receptors in response to more test over time. It’s why you can’t permanently run gear at high dosages (well …theres more to it but for this example this is enough).
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Like when a person with a really shitty diet keeps constantly eating sugary food that causes very frequent insulin spikes, the body develops insulin resistance (two totally different things but a similar concept).
Thanks for the explanation though, I appreciate it.
The heart picture thing is just a joke that I like to make, it’s the first thing I think about when I think about very high doses of gear and people who ask why they can’t stay on 600mg/wk.
Would taking antidepressants on a cycle with deca have any effect at reducing neg impact?
@Beyond_Beyond I’ve seen Wellbutrin work fairly well. But that is because it raises dopaimime.
@physioLojik if Deca messes with seratonin levels, would I be right in thinking it’d be a really bad choice for someone with depression?
@Graemsay absolutely a terrible idea. Same as tren. Stay away.
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Thanks @physioLojik.
I wasn’t planning on ever touching Teen. That stuff scares me!
You’re misinformed. Nandrolone activates the Androgen Receptor just fine. Read about Deca only cycles (Taeian talks about it all the time, so before you make it sound like I’m some lonely weirdo, do your own research). Get your e2 in range, and your libido will skyrocket.
Again, Deca dick isn’t a thing. What’s happening though, is not enough Deca (if used as a standalone drug) yielding low e2 which is terrible for your libido and physiology, or a misunderstanding of the Nandrolone+Testosterone combination which leads to more imbalance in the androgen v estrogen department.
Tricky drug to manage, but in and of itself, it’s certainly not that impotence drug people report it to be. On a Deca only cycle, my estradiol was barely 13 pg/mL on 750 mg/wk. Libido was fine, nothing crazy. Adjusted the dose up to 1.25g. Sex drive became insane. Do you guys know many people who went this route?
Again, not pushing Deca only cycles, as I believe they’re quite inferior to Testosterone, provided DHT is kept low. And as @physioLojik said, there’s more to it than muscles&penis. Believe it or not… I care about brain health just as much as I care about body health. The serotonin data is concerning.
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What about the data suggesting nandrolone is far more damaging to endothelium compared to testosterone? Besides the neuro issues, the supposed harshness (in vitro) of nand on endothelial cells reaaaaallllllly put me off + nandrolone appears to promote oxidive stress moreso than testosterone and various other anabolics.
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Whatever the reason for deca dick, dismissing those that have the problem is not helping anyone. Just because you didn’t get it doesn’t mean squat, or that you have all the answers. Maybe it was just dumb luck that you didn’t have problems rather than you being smarter than everyone else.
Do a search on here and you will find many people that have deca or tren dick problems and you can bet they tried all the recommendations and none of the suggestions given have really helped.
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I disagree with this last post. You can be as passive aggressive as you want, people who use enough Deca by itself so that their e2 is in check don’t suddenly get limp penises because of some penis-related mechanism. People who stack Deca with Test are in for a wild ride and they’re left trying to figure out their sweet spot. They rarely go for Deca only over 1 gram per week tho. If they do, please link them as I’d be curious to see their anecdotes conflicting with all of Taeian Clarke’s followers.
Mood and libido can be affected, but the penis still functions. Those are two different things. I think this article is layman enough. I did not extensively review their sources but it is in line with the discussions ITT
@unreal24278 indeed, nandrolone based drugs aren’t exactly exciting IMO. One of the potential reasons for Nandrolone’s harshness is how androgenic it is (if not 5alpha reduced) compared to how little estradiol it yields. It does have an estrogenic effect but mostly / only activates ERa. For TRT, I like Testosterone and Estradiol and that’s about it. SARMs could be promising. Everything else, 19 nors, DHTs, 17aa’s… you don’t use them for health at all. They’re quite outdated, dangerous drugs to me.
So again, not exactly saying Nandrolone is awesome, and some papers suggesting it for HRT make me facepalm hard. It builds muscle, and it doesn’t kill any penile related mechanism I can think of. Just like other androgens, if anything, Deca will give good erections. That is, if you aren’t depressed.
Don’t get me wrong, I’m not your conventional cyclist. I dont feel test has to be in every cycle and I’m always open to trying new things (not a sexual innuendo).
With regards to your stance on deca as a sole compound, what’s the science behind it? Do you have studies? I presume NPP only would also yield the same results?
I did check out Taeiens site, but didn’t find any links to any studies on PubMed. Although he does have a point, all the sides we see now compared to old bodybuilders seem to be high testosterone sides.
@tontongg
SB
You can call my post passive aggressive, or just plain old aggressive if you like, take it any way you want. My point still stands, there are a wide range of reactions to the same drug by different people. Some people don’t get negative sides from deca at all, and aren’t doing anything special by accident or design.
Change the negative side effect of deca dick, to acne or hair loss from a high androgenic steroid. Some people will get acne or hair loss, another person might get zero sides from taking the same amount. Telling them to follow the protocol that you attribute to your success, probably won’t effect the other persons results in a positive manner at all. It would be nice to think that you are universally right, but I have seen too many blood panels from other people with everything back in normal range, including(e2)but they still have deca dick.
I’m on a low dose of deca right now. My dick has gone tiny when it’s not erect! It’s normal when hard though so I’m not too bothered. Just need to hide it when in public toilets 
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Weeeellllllllllllllllllllllllllll, it depends, we don’t really use supraphysiologic doses of testosterone for health do we lol. The argument I have with some C17AA’s (such as Dbol) is the fact that one can (esp on TRT) use them for a far shorter period of time and get quite a bit out of said short time. I’d far prefer to use Dbol for 4 weeks than to use test for 16 wks as most lethal consequences from AAS (particularly involving structure and function of the heart) tend to stem from longg term use, thus in my opinion, the shorter a cycle the better + data has shown accruation in LBM tends to taper off after 6-8 wks or so as the body adjusts and reaches homeostasis again
While one can use shorter esters or unesterified gear (this is my most preferred option), many don’t want to indulge in ED shots
This comment is absolutely correct. Your “set up” before cycling dictates your outcome.
Hi there,I need to ask instead of test enanthate,can I use test cyp.?