[Case Thread] 3 Years of TRT

Hey @KSman, can you please help interpret my labs?

I was taking 20mg tamoxifen EOD with my testosterome cream and then stopped the cream on a Friday and got these labs monday morning. A confounding thing is the fact that I take modafinil daily, which sounds like it competes for the same enzyme that converts the prodrug tamoxifen into its useful metabolites. Modafinil has a 15 hr halflife, so I stopped that on Friday as well and didn’t take it on Monday. Another complication is that this is year old liquid tamoxifen from a research chem site, so not sure how much has degraded or not. I really don’t know what these means, there is existent testosterone, yet nonexistent LSH/FSH.

Perhaps this was an exercise in futility, but maybe you see other useful data?

Also, my temperatures have normalized.

CBC With Differential/Platelet
WBC 5.3 x10E3/uL 3.4 - 10.8 01
RBC 4.89 x10E6/uL 4.14 - 5.80 01
Hemoglobin 15.2 g/dL 13.0 - 17.7 01
Hematocrit 44.2 % 37.5 - 51.0 01
MCV 90 fL 79 - 97 01
MCH 31.1 pg 26.6 - 33.0 01
MCHC 34.4 g/dL 31.5 - 35.7 01
RDW 12.5 % 12.3 - 15.4 01
Platelets 257 x10E3/uL 150 - 379 01
Neutrophils 47 % Not Estab. 01
Lymphs 43 % Not Estab. 01
Monocytes 7 % Not Estab. 01
Eos 3 % Not Estab. 01
Basos 0 % Not Estab. 01
Neutrophils (Absolute) 2.5 x10E3/uL 1.4 - 7.0 01
Lymphs (Absolute) 2.3 x10E3/uL 0.7 - 3.1 01
Monocytes(Absolute) 0.4 x10E3/uL 0.1 - 0.9 01
Eos (Absolute) 0.1 x10E3/uL 0.0 - 0.4 01
Baso (Absolute) 0.0 x10E3/uL 0.0 - 0.2 01
Immature Granulocytes 0 % Not Estab. 01
Immature Grans (Abs) 0.0 x10E3/uL 0.0 - 0.1 01
Testosterone Free, Profile I
Albumin 4.6 g/dL 3.5 - 5.5 01
Testosterone, Serum 549 ng/dL 264 - 916 01
Adult male reference interval is based on a population of
healthy nonobese males (BMI <30) between 19 and 39 years old.
Travison, et.al. JCEM 2017,102;1161-1173. PMID: 28324103.
Sex Horm Binding Glob, Serum 47.6 nmol/L 16.5 - 55.9 01
Testost., Free, Calc 89.5 pg/mL 47.7 - 173.9
PSA (Reflex To Free) (Serial)
Prostate Specific Ag, Serum 0.8 ng/mL 0.0 - 4.0 01
Roche ECLIA methodology.
According to the American Urological Association, Serum PSA should
decrease and remain at undetectable levels after radical
prostatectomy. The AUA defines biochemical recurrence as an initial
PSA value 0.2 ng/mL or greater followed by a subsequent confirmatory
PSA value 0.2 ng/mL or greater.
Values obtained with different assay methods or kits cannot be used
interchangeably. Results cannot be interpreted as absolute evidence
of the presence or absence of malignant disease.
Reflex Criteria 01
The percent free PSA is performed on a reflex basis only when the
total PSA is between 4.0 and 10.0 ng/mL.
T4+Free T4
Thyroxine (T-4), Serum 7.2 ug/dL 03
Reference Range:
Adults: 4.2 - 13.0
Free T4 by Dialysis/Mass Spec
1.3 ng/dL 03
Reference Range:
Pubertal Children and Adults:
0.8 - 1.7
FSH and LH
LH <0.2 Low mIU/mL 1.7 - 8.6 01
FSH <0.2 Low mIU/mL 1.5 - 12.4 01
Testosterone,Free and Total
Free Testosterone(Direct) 14.3 pg/mL 9.3 - 26.5 04
T3, Free, Dialysis, LC/MS-MS 5.45 pg/mL 03
Reference Range:
Range Mean
Children >10y
and Adults: 1.81 - 4.06 2.77
Pregnant Females:
First Trimester 1.6 - 3.3 2.5
Second Trimester To be determined
Third Trimester 1.0 - 3.2 2.1
DHEA, Serum
Dehydroepiandrosterone (DHEA)
369 ng/dL 31 - 701 04
Age
1 - 5 years 0 - 67
6 - 7 years 0 - 110
8 - 10 years 0 - 185
11 - 12 years 0 - 201
13 - 14 years 0 - 318
15 - 16 years 39 - 481
17 - 19 years 40 - 491
19 years 31 - 701
Disclaimer: 04
This test was developed and its performance characteristics
determined by LabCorp. It has not been cleared or approved
by the Food and Drug Administration.
TSH 2.630 uIU/mL 0.450 - 4.500 01
Estradiol 7.8 pg/mL 7.6 - 42.6 01
Roche ECLIA methodology
Reverse T3, Serum 22.4 ng/dL 9.2 - 24.1 04
Thyroid Antibodies
Thyroid Peroxidase (TPO) Ab 11 IU/mL 0 - 34 01
Thyroglobulin Antibody <1.0 IU/mL 0.0 - 0.9 01
Thyroglobulin Antibody measured by Beckman Coulter Methodology